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      The efficacy and safety of health qigong for anti-aging : Protocol for a systematic review and meta-analysis

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          Abstract

          Background:

          Aging is a phenomenon that human's physiology and psychology is progressive decline for natural environment. Health Qigong, as a convenient and effective exercise therapy,is widely used for anti-aging. However, there are no systematic reviews or meta-analysises to evaluate the efficacy and safety of Health Qigong on anti-aging.

          Methods:

          We will systematically search for 7 English databases(PubMed, Excerpta Medica Database, MEDLINE, Web of Science, Cochrane Library, SpringerLink, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases(namely the China National Knowledge Infrastructure Database, the Wanfang Database, the Chinese Scientific Journal Database, and the Chinese BioMedical Literature Database) from their inceptions to August 2020. Randomized controlled trials (RCTs) using Health Qigong to anti-aging will be included. After the selection and extraction of eligible studies, a meta-analysis will be undertaken to assess the efficacy and safety of Health Qigong on anti-aging. Moreover, study selection, data extraction, and the evaluation of the methodological quality of trials will each be independently completed by at least 2 researchers. The Review Manager Software V.5.3 will be employed for meta-analysis to assess the risk of bias, data synthesis, and subgroup analysis.

          Results:

          This review will provide the latest knowledge and evidence on the efficacy and safety of Health Qigong for anti-aging through the analysis of various evaluation scales.

          Conclusion:

          The conclusion of this review will help clinicians provide effective exercise therapy for anti-aging.

          Registration number:

          INPLASY202090017

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          Most cited references18

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          • Article: found

          The Hallmarks of Aging

          Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. This Review enumerates nine tentative hallmarks that represent common denominators of aging in different organisms, with special emphasis on mammalian aging. These hallmarks are: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. A major challenge is to dissect the interconnectedness between the candidate hallmarks and their relative contributions to aging, with the final goal of identifying pharmaceutical targets to improve human health during aging, with minimal side effects. Copyright © 2013 Elsevier Inc. All rights reserved.
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            How stem cells age and why this makes us grow old.

            Recent data suggest that we age, in part, because our self-renewing stem cells grow old as a result of heritable intrinsic events, such as DNA damage, as well as extrinsic forces, such as changes in their supporting niches. Mechanisms that suppress the development of cancer, such as senescence and apoptosis, which rely on telomere shortening and the activities of p53 and p16(INK4a), may also induce an unwanted consequence: a decline in the replicative function of certain stem-cell types with advancing age. This decreased regenerative capacity appears to contribute to some aspects of mammalian ageing, with new findings pointing to a 'stem-cell hypothesis' for human age-associated conditions such as frailty, atherosclerosis and type 2 diabetes.
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              Free radical theory of aging

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                Author and article information

                Journal
                Medicine (Baltimore)
                Medicine (Baltimore)
                MEDI
                Medicine
                Lippincott Williams & Wilkins (Hagerstown, MD )
                0025-7974
                1536-5964
                4 December 2020
                04 December 2020
                : 99
                : 49
                : e22877
                Affiliations
                [a ]Basic Medical College, Chengdu University of TCM
                [b ]Hospital of Chengdu University of Traditional Chinese Medicine.
                Author notes
                []Correspondence: Weihong Li, Basic Medical College, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China (e-mail: lwh@ 123456cdutcm.edu.cn ).
                Article
                MD-D-20-08849 22877
                10.1097/MD.0000000000022877
                7717840
                a76b704e-8501-4330-922e-bafd371ced6f
                Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.

                This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0

                History
                : 17 September 2020
                : 24 September 2020
                Funding
                Funded by: the national natural science foundation of China
                Award ID: 81873204
                Award Recipient : Weihong Li
                Funded by: the national key research and development program of China
                Award ID: 2017YFC1703304
                Award Recipient : Weihong Li
                Categories
                7000
                Research Article
                Study Protocol Systematic Review
                Custom metadata
                TRUE
                UNITED STATES

                aging,anti-aging,health qigong,systematic review
                aging, anti-aging, health qigong, systematic review

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