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      Reward Capacity Predicts Leptin Dynamics During Laboratory-Controlled Eating in Women as a Function of Body Mass Index

      , Ph.D a , b , , Ph.D., M.P.H c

      Obesity (Silver Spring, Md.)

      leptin, reward capacity, pleasure, body mass index, women

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          Abstract

          Objective

          The role of leptin in mesolimbic signaling non-food-related reward has been well established at the pre-clinical level, yet studies in humans are lacking. The present investigation explored the association between hedonic capacity and leptin dynamics, and whether this association differed by BMI class.

          Methods

          In this cross-sectional study of 75 women (42 with lean BMIs, 33 with obese BMIs), we measured serum leptin before/after meal consumption. Reward capacity was assessed using the Snaith-Hamilton Pleasure Scale (SHAPS). Multiple regression tested whether reward capacity was associated with leptin AUC, with an interaction term to test differences between lean (LN) and obese (OB) groups.

          Results

          The interaction of SHAPS by BMI group was robust (β=−.40, p=.005); among women with obesity, greater SHAPS score was associated with lower leptin AUC (β=−.35, p=.002, adjusted R-squared=.66). Among the lean group, the association was not statistically significant (β=−.16, p=.252, adjusted R-squared=.22). Findings were above and beyond BMI and age.

          Conclusions

          In this sample a robust, negative association between reward capacity and circulating leptin was stronger in women with obesity compared to lean counterparts. These findings suggest that despite likely leptin resistance, inhibitory leptin functioning related to non-food reward may be spared in women with obesity.

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          Most cited references 24

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          Distribution Theory for Glass's Estimator of Effect size and Related Estimators

           L. Hedges (1981)
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            A scale for the assessment of hedonic tone the Snaith-Hamilton Pleasure Scale.

            Hedonic tone and its absence, anhedonia, are important in psychopathological research, but instruments for their assessment are lengthy and probably culturally biased. A new scale was constructed from the responses of a large sample of the general population to a request to list six situations which afforded pleasure. The most frequent items were reviewed and those likely to be affected by cultural setting, age, or sex were removed. A pilot study led to an abbreviated scale of 14 items, covering four domains of pleasure response. This questionnaire was subjected to psychometric evaluation in new samples from the general population and psychiatric patients. The scale was found to have a score range that would distinguish a 'normal' from an 'abnormal' response. Validity and reliability were found to be satisfactory. The new scale, the Snaith-Hamilton Pleasure Scale (SHAPS), is an instrument which may be recommended for psychopathological research.
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              Leptin receptor signaling in midbrain dopamine neurons regulates feeding.

              The leptin hormone is critical for normal food intake and metabolism. While leptin receptor (Lepr) function has been well studied in the hypothalamus, the functional relevance of Lepr expression in the ventral tegmental area (VTA) has not been investigated. The VTA contains dopamine neurons that are important in modulating motivated behavior, addiction, and reward. Here, we show that VTA dopamine neurons express Lepr mRNA and respond to leptin with activation of an intracellular JAK-STAT pathway and a reduction in firing rate. Direct administration of leptin to the VTA caused decreased food intake while long-term RNAi-mediated knockdown of Lepr in the VTA led to increased food intake, locomotor activity, and sensitivity to highly palatable food. These data support a critical role for VTA Lepr in regulating feeding behavior and provide functional evidence for direct action of a peripheral metabolic signal on VTA dopamine neurons.
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                Author and article information

                Journal
                101264860
                32902
                Obesity (Silver Spring)
                Obesity (Silver Spring)
                Obesity (Silver Spring, Md.)
                1930-7381
                1930-739X
                23 June 2017
                19 July 2017
                September 2017
                19 January 2018
                : 25
                : 9
                : 1564-1568
                Affiliations
                [a ]Division of Women’s Health, Department of Medicine, and Department of Psychiatry, Boston, MA, United States of America
                [b ]Harvard Medical School, Boston, MA United States of America
                [c ]Department of Psychology, Smith College, Northampton, MA, United States of America
                Author notes
                Corresponding Author: Laura M. Holsen, Ph.D., Division of Women’s Health, BC-3, 1620, Tremont St., Boston, MA 02120, Office: (617) 525-8772, Fax: (617) 525-7900, lholsen@ 123456partners.org
                [*]

                Co-first authors (denotes equal contribution)

                NIHMS886675
                10.1002/oby.21930
                5573628
                28722317

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                Categories
                Article

                Medicine

                leptin, women, body mass index, pleasure, reward capacity

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