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      Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.

      1 ,

      Genes & development

      Cold Spring Harbor Laboratory

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          Abstract

          Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of gene control in humans. It provides cells with the opportunity to create protein isoforms of differing, even opposing, functions from a single gene. Cancer cells often take advantage of this flexibility to produce proteins that promote growth and survival. Many of the isoforms produced in this manner are developmentally regulated and are preferentially re-expressed in tumors. Emerging insights into this process indicate that pathways that are frequently deregulated in cancer often play important roles in promoting aberrant splicing, which in turn contributes to all aspects of tumor biology.

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          Author and article information

          Journal
          Genes Dev
          Genes & development
          Cold Spring Harbor Laboratory
          1549-5477
          0890-9369
          Nov 01 2010
          : 24
          : 21
          Affiliations
          [1 ] Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
          Article
          24/21/2343
          10.1101/gad.1973010
          2964746
          21041405

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