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      Hypoglycemia after Gastric Bypass Surgery: Current Concepts and Controversies

      1 , 2 , 3 , 4
      The Journal of Clinical Endocrinology & Metabolism
      The Endocrine Society

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          Abstract

          <div class="section"> <a class="named-anchor" id="s1"> <!-- named anchor --> </a> <h5 class="section-title" id="d8278544e167">Context</h5> <p id="d8278544e169">Hypoglycemia, occurring after bariatric and other forms of upper gastrointestinal surgery, is increasingly encountered by clinical endocrinologists. The true frequency of this condition remains uncertain, due, in part, to differences in the diagnostic criteria and in the affected populations, as well as relative lack of patient and physician awareness and understanding of this condition. Postbariatric hypoglycemia can be severe and disabling for some patients, with neuroglycopenia (altered cognition, seizures, and loss of consciousness) leading to falls, motor vehicle accidents, and job and income loss. Moreover, repeated episodes of hypoglycemia can result in hypoglycemia unawareness, further impairing safety and requiring the assistance of others to treat hypoglycemia. </p> </div><div class="section"> <a class="named-anchor" id="s2"> <!-- named anchor --> </a> <h5 class="section-title" id="d8278544e172">Objective</h5> <p id="d8278544e174">In this review, we summarize and integrate data from studies of patients affected by hypoglycemia after Roux-en-Y gastric bypass (RYGB) surgery, obtained from PubMed searches (1990 to 2017) and reference searches of relevant retrieved articles. Whereas hypoglycemia can also be observed after sleeve gastrectomy and fundoplication, this review is focused on post-RYGB, given the greater body of published clinical studies at present. </p> </div><div class="section"> <a class="named-anchor" id="s3"> <!-- named anchor --> </a> <h5 class="section-title" id="d8278544e177">Outcome Measures</h5> <p id="d8278544e179">Data addressing specific aspects of diagnosis, pathophysiology, and treatment were reviewed by the authors; when not available, the authors have provided opinions based on clinical experience with this challenging condition. </p> </div><div class="section"> <a class="named-anchor" id="s4"> <!-- named anchor --> </a> <h5 class="section-title" id="d8278544e182">Conclusions</h5> <p id="d8278544e184">Hypoglycemia, occurring after gastric bypass surgery, is challenging for patients and physicians alike. This review provides a systematic approach to diagnosis and treatment based on the underlying pathophysiology. </p> </div><p class="first" id="d8278544e187">Hypoglycemia is increasingly recognized after gastric bypass. This review summarizes the pathophysiology of this challenging syndrome and provides suggested approaches to diagnosis and treatment. </p>

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          Author and article information

          Journal
          The Journal of Clinical Endocrinology & Metabolism
          The Endocrine Society
          0021-972X
          1945-7197
          May 04 2018
          May 04 2018
          Affiliations
          [1 ]University of Texas Health at San Antonio, Diabetes Division, San Antonio, TX
          [2 ]Mayo Clinic, Rochester, MN
          [3 ]Stanford University, Palo Alto, CA
          [4 ]Research and Clinic Divisions, Joslin Diabetes Center, and Harvard Medical School, Boston, MA
          Article
          10.1210/jc.2018-00528
          6692713
          30101281
          a77a273e-0a0d-4d42-835a-50bbe99a79d8
          © 2018
          History

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