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      The flexizyme system: a highly flexible tRNA aminoacylation tool for the translation apparatus

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      Current Opinion in Chemical Biology
      Elsevier BV

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          Abstract

          Flexizymes are de novo ribozymes capable of charging a wide variety of non-natural amino acids on tRNAs. The flexizyme system enables reprogramming of the genetic code by reassigning the codons that are generally assigned to natural amino acids to non-natural residues, and thus mRNA-directed synthesis of non-natural polypeptides can be achieved. In this review, we comprehensively summarize the history of the flexizyme system and its subsequent development into a practical tool. Furthermore, applications to the synthesis of novel biopolymers via genetic code reprogramming and perspectives for future applications are described.

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          Author and article information

          Journal
          Current Opinion in Chemical Biology
          Current Opinion in Chemical Biology
          Elsevier BV
          13675931
          October 2007
          October 2007
          : 11
          : 5
          : 537-542
          Article
          10.1016/j.cbpa.2007.08.011
          17884697
          a79fd445-6192-4f7d-92da-bfbd59301101
          © 2007

          https://www.elsevier.com/tdm/userlicense/1.0/

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