Using Environment-Sensitive Fluorescent Probes to Characterize Liquid-Liquid Phase Separation in Supersaturated Solutions of Poorly Water Soluble Compounds.

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Abstract

Highly supersaturated aqueous solutions of poorly soluble compounds can undergo liquid-liquid phase separation (LLPS) when the concentration exceeds the "amorphous solubility". This phenomenon has been widely observed during high throughput screening of new molecular entities as well as during the dissolution of amorphous solid dispersions. In this study, we have evaluated the use of environment-sensitive fluorescence probes to investigate the formation and properties of the non-crystalline drug-rich aggregates formed in aqueous solutions as a result of LLPS.

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Journal

Journal ID (iso-abbrev): Pharm Res

Title: Pharmaceutical research

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1573-904X

ISSN (Print): 0724-8741

Publication date (Electronic): Nov 2015

Volume: 32

Issue: 11

Affiliations

[1 ] Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907, USA.

[2 ] Manufacturing Science and Technology, AbbVie Inc, North Chicago, Illinois, USA.

[3 ] Drug Product Development, Research and Development, AbbVie Inc, North Chicago, Illinois, USA.

[4 ] Formulation & Process Development, Gilead Sciences, Inc, Foster City, California, USA.

[5 ] Analytical Sciences, Manufacturing Science and Technology, AbbVie Inc, North Chicago, Illinois, USA.

[6 ] Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907, USA. lstaylor@purdue.edu.

Article

Publisher Item ID: 10.1007/s11095-015-1725-z

DOI: 10.1007/s11095-015-1725-z

PubMed ID: 26123681

SO-VID: a7a77356-fa57-4d8a-90f1-e6d2636e3cdd

History

Keywords: Fluorescence,Phase separation,Supersaturation

Data availability:

Keywords: Fluorescence, Phase separation, Supersaturation

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