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      Social Costs of Iron Deficiency Anemia in 6–59-Month-Old Children in India

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          Abstract

          Introduction

          Inadequate nutrition has a severe impact on health in India. According to the WHO, iron deficiency is the single most important nutritional risk factor in India, accounting for more than 3% of all disability-adjusted life years (DALYs) lost. We estimate the social costs of iron deficiency anemia (IDA) in 6–59-month-old children in India in terms of intangible costs and production losses.

          Materials and Methods

          We build a health economic model estimating the life-time costs of a birth cohort suffering from IDA between the ages of 6 and 59 months. The model is stratified by 2 age groups (6–23 and 24–59-months), 2 geographical areas (urban and rural), 10 socio-economic strata and 3 degrees of severity of IDA (mild, moderate and severe). Prevalence of anemia is calculated with the last available National Family Health Survey. Information on the health consequences of IDA is extracted from the literature.

          Results

          IDA prevalence is 49.5% in 6–23-month-old and 39.9% in 24–58-month-old children. Children living in poor households in rural areas are particularly affected but prevalence is high even in wealthy urban households. The estimated yearly costs of IDA in 6–59-month-old children amount to intangible costs of 8.3 m DALYs and production losses of 24,001 m USD, equal to 1.3% of gross domestic product. Previous calculations have considerably underestimated the intangible costs of IDA as the improved WHO methodology leads to a threefold increase of DALYs due to IDA.

          Conclusion

          Despite years of iron supplementation programs and substantial economic growth, IDA remains a crucial public health issue in India and an obstacle to the economic advancement of the poor. Young children are especially vulnerable due to the irreversible effects of IDA on cognitive development. Our research may contribute to the design of new effective interventions aiming to reduce IDA in early childhood.

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          Most cited references14

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          Maternal and child undernutrition and overweight in low-income and middle-income countries

          The Lancet, 382(9890), 427-451
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            GBD 2010: design, definitions, and metrics.

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              An analysis of anemia and child mortality.

              The relationship of anemia as a risk factor for child mortality was analyzed by using cross-sectional, longitudinal and case-control studies, and randomized trials. Five methods of estimation were adopted: 1) the proportion of child deaths attributable to anemia; 2) the proportion of anemic children who die in hospital studies; 3) the population-attributable risk of child mortality due to anemia; 4) survival analyses of mortality in anemic children; and 5) cause-specific anemia-related child mortality. Most of the data available were hospital based. For children aged 0-5 y the percentage of deaths due to anemia was comparable for reports from highly malarious areas in Africa (Sierra Leone 11.2%, Zaire 12.2%, Kenya 14.3%). Ten values available for hemoglobin values <50 g/L showed a variation in case fatality from 2 to 29.3%. The data suggested little if any dose-response relating increasing hemoglobin level (whether by mean value or selected cut-off values) with decreasing mortality. Although mortality was increased in anemic children with hemoglobin <50 g/L, the evidence for increased risk with less severe anemia was inconclusive. The wide variation for mortality with hemoglobin <50 g/L is related to methodological variation and places severe limits on causal inference; in view of this, it is premature to generate projections on population-attributable risk. A preliminary survival analysis of an infant cohort from Malawi indicated that if the hemoglobin decreases by 10 g/L at age 6 mo, the risk of dying becomes 1.72 times higher. Evidence from a number of studies suggests that mortality due to malarial severe anemia is greater than that due to iron-deficiency anemia. Data are scarce on anemia and child mortality from non-malarious regions. Primary prevention of iron-deficiency anemia and malaria in young children could have substantive effects on reducing child mortality from severe anemia in children living in malarious areas.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                27 August 2015
                2015
                : 10
                : 8
                : e0136581
                Affiliations
                [1 ]Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland
                [2 ]International Clinical Epidemiology Network, INCLEN, New Delhi, India
                University College London, UNITED KINGDOM
                Author notes

                Competing Interests: The authors have the following interests. The study was supported by the Nestlé Research Center. KE and SW have received speaker honorarium and conference travel grants from Nestlé Nutrition Institute. Rafael Plessow, Beatrice Brunner, Christina Tzogiou, Klaus Eichler, Urs Brügger and Simon Wieser are employed by Winterthur Institute of Health Economics. The Winterthur Institute of Health Economics is an institute at the Zurich University of Applied Sciences, a publicly funded Swiss University. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

                Conceived and designed the experiments: RP NKA UB SW. Performed the experiments: RP BB CT SW. Analyzed the data: RP BB CT. Contributed reagents/materials/analysis tools: RP BB CT KE. Wrote the paper: RP NKA SW.

                Article
                PONE-D-15-17067
                10.1371/journal.pone.0136581
                4552473
                26313356
                a7b16939-9a03-4f02-a8f7-6dca7bd28004
                Copyright @ 2015

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

                History
                : 20 April 2015
                : 5 August 2015
                Page count
                Figures: 7, Tables: 6, Pages: 16
                Funding
                The study was supported by the Nestlé Research Center. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. KE and SW have received speaker honorarium and conference travel grants from Nestlé Nutrition Institute. Winterthur Institute of Health Economics provided support in the form of salaries for authors RP, BB, CT, KE, UB and SW, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The Winterthur Institute of Health Economics is an institute at the Zurich University of Applied Sciences, a publicly funded Swiss University. The specific roles of these authors are articulated in the ‘author contributions’ section.
                Categories
                Research Article
                Custom metadata
                All relevant data are within the paper or are publicly available without restriction. In addition to the data within the paper, we analyzed the following dataset: International Institute for Population Sciences (IIPS) and Macro International. National Family Health Survey (NFHS-3), 2005–06: India [Dataset]. Mumbai: IIPS; 2007. NFHS-3 data are available at http://www.dhsprogram.com/data/dataset/India_Standard-DHS_2006.cfm?flag=0.

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