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      Characteristics and outcomes of SARS‐CoV‐2 infection in Victorian children at a tertiary paediatric hospital

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          Abstract

          Aim

          Victoria experienced two ‘waves’ of COVID‐19 between March and September 2020 and more cases than any other jurisdiction in Australia. Although world‐wide reports of COVID‐19 reflect that children are less likely to experience severe disease compared with adults, hospitalisations and deaths have been reported. We report testing and outcomes of children with SARS‐CoV‐2 infection presenting to a tertiary paediatric hospital in Melbourne.

          Methods

          We conducted a prospective cohort study at The Royal Children's Hospital (RCH), including all children and adolescents (aged 0–18 years) who presented and were tested for SARS‐CoV‐2 over a 6‐month period, between 21 March 2020, up to the 21 September 2020. Detailed epidemiological and clinical data were recorded.

          Results

          A total of 19 708 tests for SARS‐CoV‐2 were performed in 14 419 patients. One hundred and eighty patients tested positive for SARS‐CoV‐2 (1.2%). 110 (61%) were symptomatic, 60 (33%) were asymptomatic and 10 (6%) were pre‐symptomatic. Close contacts of a positive case were associated with a higher risk of a testing positive for SARS‐CoV‐2 (120/2027 (6%) vs. 60/14589 (0.4%), RD 5.5 (95% CI 4.5 to 6.5), P < 0.001). Eighteen (10%) SARS‐CoV‐2‐positive patients were admitted to hospital with one patient requiring intensive care. All patients recovered fully with no deaths.

          Conclusion

          In Victorian children presenting to a tertiary hospital, SARS‐CoV‐2 infection caused predominantly mild or asymptomatic infection, with most children not requiring hospitalisation.

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          Most cited references25

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          Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

          Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data capture tools to support clinical and translational research. We present: (1) a brief description of the REDCap metadata-driven software toolset; (2) detail concerning the capture and use of study-related metadata from scientific research teams; (3) measures of impact for REDCap; (4) details concerning a consortium network of domestic and international institutions collaborating on the project; and (5) strengths and limitations of the REDCap system. REDCap is currently supporting 286 translational research projects in a growing collaborative network including 27 active partner institutions.
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            Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

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              Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China

              To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China.
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                Author and article information

                Contributors
                shidan.tosif@rch.org.au
                Journal
                J Paediatr Child Health
                J Paediatr Child Health
                10.1111/(ISSN)1440-1754
                JPC
                Journal of Paediatrics and Child Health
                John Wiley & Sons Australia, Ltd. (Australia )
                1034-4810
                1440-1754
                25 October 2021
                25 October 2021
                : 10.1111/jpc.15786
                Affiliations
                [ 1 ] Department of Paediatrics University of Melbourne Melbourne Victoria Australia
                [ 2 ] Infection and Immunity Murdoch Children 's Research Institute Melbourne Victoria Australia
                [ 3 ] Departments of General Medicine The Royal Children's Hospital Melbourne Victoria Australia
                [ 4 ] Hospital‐in‐the‐Home Department The Royal Children's Hospital Melbourne Victoria Australia
                [ 5 ] Melbourne School of Population and Global Health The University of Melbourne Melbourne Victoria Australia
                [ 6 ] Department of Respiratory Medicine The Royal Children's Hospital Melbourne Victoria Australia
                [ 7 ] Infectious Diseases Unit, Department of General Medicine The Royal Children's Hospital Melbourne Victoria Australia
                [ 8 ] Intensive Care Unit The Royal Children's Hospital Melbourne Victoria Australia
                [ 9 ] Emergency Department The Royal Children's Hospital Melbourne Victoria Australia
                [ 10 ] Emergency Research, Clinical Sciences Murdoch Children 's Research Institute Melbourne Victoria Australia
                Author notes
                [*] [* ] Correspondence: Dr Shidan Tosif, Infection and Immunity, Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Vic. 3052, Australia. Fax: +61 3 9345 4163; email: shidan.tosif@ 123456rch.org.au

                Author information
                https://orcid.org/0000-0003-0022-1009
                https://orcid.org/0000-0001-5455-957X
                https://orcid.org/0000-0003-2917-2773
                https://orcid.org/0000-0002-9710-6113
                https://orcid.org/0000-0003-4637-1416
                https://orcid.org/0000-0002-1107-2187
                Article
                JPC15786
                10.1111/jpc.15786
                8662161
                34693586
                a7b63502-16ac-4c5e-b388-4d7ba6bb483f
                © 2021 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

                This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

                History
                : 10 August 2021
                : 17 March 2021
                : 17 September 2021
                Page count
                Figures: 1, Tables: 2, Pages: 6, Words: 4134
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                corrected-proof
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.9 mode:remove_FC converted:10.12.2021

                covid‐19,general paediatrics,infectious disease
                covid‐19, general paediatrics, infectious disease

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