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      Glucose transporters in the 21st Century.

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          Abstract

          The ability to take up and metabolize glucose at the cellular level is a property shared by the vast majority of existing organisms. Most mammalian cells import glucose by a process of facilitative diffusion mediated by members of the Glut (SLC2A) family of membrane transport proteins. Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. The primary physiological substrates for at least half of the 14 Glut proteins are either uncertain or unknown. The well-established glucose transporter isoforms, Gluts 1-4, are known to have distinct regulatory and/or kinetic properties that reflect their specific roles in cellular and whole body glucose homeostasis. Separate review articles on many of the Glut proteins have recently appeared in this journal. Here, we provide a very brief summary of the known properties of the 14 Glut proteins and suggest some avenues of future investigation in this area.

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          Author and article information

          Journal
          Am J Physiol Endocrinol Metab
          American journal of physiology. Endocrinology and metabolism
          American Physiological Society
          1522-1555
          0193-1849
          Feb 2010
          : 298
          : 2
          Affiliations
          [1 ] Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
          Article
          ajpendo.00712.2009
          10.1152/ajpendo.00712.2009
          2822486
          20009031
          a7b7ed57-9944-4bec-bf0a-1822e688628b
          History

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