1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia.

      Trends in Neurosciences
      Alzheimer Disease, complications, diagnosis, pathology, Biological Markers, metabolism, Cognition Disorders, etiology, Dementia, Disease Progression, Early Diagnosis, Humans, Mild Cognitive Impairment, Neuroimaging, methods, Predictive Value of Tests

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. At the time of clinical manifestation of dementia, significant irreversible brain damage is already present, rendering the diagnosis of AD at early stages of the disease an urgent prerequisite for therapeutic treatment to halt, or at least slow, disease progression. In this review, we discuss various neuroimaging measures that are proving to have potential value as biomarkers of AD pathology for the detection and prediction of AD before the onset of dementia. Recent studies that have identified AD-like structural and functional brain changes in elderly people who are cognitively within the normal range or who have mild cognitive impairment (MCI) are discussed. A dynamic sequence model of changes that occur in neuroimaging markers during the different disease stages is presented and the predictive value of multimodal neuroimaging for AD dementia is considered. Published by Elsevier Ltd.

          Related collections

          Author and article information

          Comments

          Comment on this article