Positional effect of single bulge nucleotide on PNA(peptide nucleic acid)/DNA hybrid stability

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Abstract

We report positional effect of bulge nucleotide on PNA/DNA hybrid stability. CD spectra showed that PNA/DNA hybrids required at least seven base pairings at a stem region to form a bulged structure. On the other hand, DNA/DNA could form bulged structure when there are only four base pairings adjacent to the bulge nucleotide. We discuss why PNA requests such a many base pairings to form bulged structure from a nearest neighbor standpoint.

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Author and article information

Journal

Title: Nucleic Acids Symposium Series

Abbreviated Title: Nucleic Acids Symposium Series

Publisher: Oxford University Press (OUP)

ISSN (Print): 0261-3166

ISSN (Electronic): 1746-8272

Publication date Created: November 01 1999

Publication date (Print): November 01 1999

Volume: 42

Issue: 1

Pages: 95-96

Article

DOI: 10.1093/nass/42.1.95

PubMed ID: 10780396

SO-VID: a7d36013-d0de-41b6-8491-4c9006a307f7

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