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      Herpes Zoster num lactente de três meses de idade Translated title: Herpes Zoster In A 3-Month-Old Infant

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          Abstract

          Introdução: O Herpes Zoster (HZ) é raro na idade pediátrica e resulta da reativação do vírus varicella-zoster, latente na raiz dorsal dos gânglios sensoriais ou dos nervos cranianos, após infeção primária (varicela). Caso Clínico: Descreve-se o caso de uma lactente de três meses de idade, previamente saudável, sem manifestações clínicas anteriores de varicela, apesar de contacto com a doença às duas semanas de vida. Internada por exantema papulo-vesicular envolvendo de forma unilateral os dermátomos L4 e L5 e medicada com aciclovir com boa evolução clínica. Conclusão: A imaturidade do sistema imunitário e a interferência dos anticorpos maternos contribuem para a manifestação do HZ no primeiro ano de vida. Numa criança previamente saudável não está recomendada a exclusão de imunodeficiência ou patologia oncológica subjacente.

          Translated abstract

          Introduction: Herpes Zoster (HZ) is rare in infancy and results from reactivation of varicella-zoster virus, latent in the dorsal root ganglia of sensory or cranial nerves after primary infection (chickenpox). Case Report: We describe the case of an healthy infant, three months old, without previous clinical symptoms of chickenpox, in spite of having contacted with the disease at two weeks of life. She was hospitalized for vesicular-papular rash involving unilaterally dermatomes L4 and L5 and was treated with acyclovir with good clinical outcome. Conclusion: The immaturity of the immune system and the interference of maternal antibodies contribute to the manifestation of HZ in the first year of life. In a previously healthy child it is not recommended the exclusion of underlying immunodeficiency or malignant disease.

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          Most cited references9

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          Prevalence of anti-varicella-zoster virus antibodies in French infants under 15 months of age.

          Varicella is a widespread disease of childhood resulting from primary infection with varicella-zoster virus (VZV). The objective of this study was to determine the kinetics of the decline of maternal anti-VZV antibodies in French infants between birth and the age of 15 months in order to estimate the duration of passively acquired maternal anti-VZV immunoglobulin G (IgG). This prospective multicenter study was conducted between October 2005 and January 2007 in the pediatric wards and/or pediatric emergency units of seven French hospitals scattered throughout the country. The level of anti-VZV IgG antibodies in serum was measured by a time-resolved fluorescence immunoassay (TRFIA) (the threshold considered positive is 150 mIU/ml). A total of 345 infants were included. Seventy-seven percent of mothers reported a history of varicella. A rapid decline in the prevalence of anti-VZV antibodies was observed during the first few months of life, with the mean antibody titer decreasing from 536 mIU/ml at birth and through 1 month to below the 150-mIU/ml threshold at 3 to 4 months. The half-life of passively acquired maternal immunoglobulins was around 6 weeks. Based on a large number of subjects, this study clearly demonstrated, for the first time in France, high levels of passively acquired maternal antibodies during the neonatal period, and it allowed us to estimate the duration of passively acquired maternal anti-VZV IgG in French infants. After 4 to 5 months, infants had very low levels of maternal anti-VZV IgG, below the 150-mIU/ml cutoff of the VZV IgG TRFIA.
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            Varicella-Zoster Virus Infections

            A Gerchon (2008)
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              Seroprevalen ce od Varicella-Zoster virus IgG antibodies in Swiss children during the first 16 months of age

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                nas
                Nascer e Crescer
                Nascer e Crescer
                Centro Hospitalar do Porto
                0872-0754
                December 2015
                : 24
                : 4
                : 179-182
                Affiliations
                [1 ] Centro Hospitalar de Lisboa Ocidental Portugal
                [2 ] Hospital de Cascais Dr. José de Almeida Portugal
                Article
                S0872-07542015000600008
                a7ddfc66-7c1a-49fb-a7e8-67aee30a7247

                http://creativecommons.org/licenses/by/4.0/

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                Product

                SciELO Portugal

                Self URI (journal page): http://www.scielo.mec.pt/scielo.php?script=sci_serial&pid=0872-0754&lng=en
                Categories
                PEDIATRICS

                Pediatrics
                Herpes zoster,varicella-zoster virus,infant,vírus varicella-zoster,lactente
                Pediatrics
                Herpes zoster, varicella-zoster virus, infant, vírus varicella-zoster, lactente

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