Corrigendum to “ In Vivo  Resistance to Ceftolozane/Tazobactam in  Pseudomonas aeruginosa  Arising by AmpC- and Non-AmpC-Mediated Pathways”

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Abstract

In the article titled “In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways” [1], a grant number was missing. The Acknowledgments section should be updated as follows. We thank Morouge Alramadhan for technical support. We also thank the Universidad El Bosque for financial support for whole genome sequencing (Grant no. PCI-2017-9447). This work was supported by the National Institutes of Health (Grant nos. K08-AI113317 (TTT) and K24-AI121296 (CAA)), the Millennium Science Initiative of the Ministry of Economy, Development and Tourism, Government of Chile (JMM), and the Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), FONDECYT 1171805, Ministry of Education, Government of Chile (JMM).

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In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways

Erik Skoglund, Henrietta Abodakpi, Rafael Ríos … (2018)

Two pairs of ceftolozane/tazobactam susceptible/resistant P. aeruginosa were isolated from 2 patients after exposure to β-lactams. The genetic basis of ceftolozane/tazobactam resistance was evaluated, and β-lactam-resistant mechanisms were assessed by phenotypic assays. Whole genome sequencing identified mutations in AmpC including the mutation (V213A) and a deletion of 7 amino acids (P210–G216) in the Ω-loop. Phenotypic assays showed that ceftolozane/tazobactam resistance in the strain with AmpCV213A variant was associated with increased β-lactamase hydrolysis activity. On the other hand, the deletion of 7 amino acids in the Ω-loop of AmpC did not display enhanced β-lactamase activity. Resistance to ceftolozane/tazobactam in P. aeruginosa is associated with changes in AmpC; however, the apparent loss of β-lactamase activity in AmpC∆7 suggests that non-AmpC mechanisms could play an important role in resistance to β-lactam/β-lactamase inhibitor combinations.

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Contributors

Truc T. Tran:

ORCID: https://orcid.org/0000-0002-2696-4196

Journal

Journal ID (nlm-ta): Case Rep Infect Dis

Journal ID (iso-abbrev): Case Rep Infect Dis

Journal ID (publisher-id): CRIID

Title: Case Reports in Infectious Diseases

Publisher: Hindawi

ISSN (Print): 2090-6625

ISSN (Electronic): 2090-6633

Publication date Collection: 2019

Publication date (Electronic): 2 September 2019

Publication date PMC-release: 2 September 2019

Volume: 2019

Electronic Location Identifier: 8314349

Affiliations

¹University of Houston College of Pharmacy, Houston, TX, USA

²Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia

³Center for Antimicrobial Resistance and Microbial Genomics, UTHealth McGovern Medical School, Houston, TX, USA

⁴Millennium Initiative for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile

⁵Grupo de Investigación en Resistencia Antimicrobiana y Epidemiología Hospitalaria–RAEH, Universidad El Bosque, Bogotá, Colombia

⁶Division of Infectious Diseases, UTHealth McGovern Medical School, Houston, TX, USA

⁷Genomics and Resistant Microbes Group, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo, Santiago, Chile

⁸Department of Microbiology and Molecular Genetics, UTHealth McGovern Medical School, Houston, TX, USA

⁹Center for Infectious Diseases, University of Texas School of Public Health, Houston, TX, USA

Author information

Erik Skoglund https://orcid.org/0000-0001-8743-5995

Javier Ardila https://orcid.org/0000-0002-1940-502X

Truc T. Tran https://orcid.org/0000-0002-2696-4196

Article

DOI: 10.1155/2019/8314349

PMC ID: 6745093

SO-VID: a7e25d93-540c-42c1-b323-da53e2bfbe30

License:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

History

Date received : 4 March 2019

Date accepted : 12 March 2019

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Corrigendum to “ In Vivo Resistance to Ceftolozane/Tazobactam in Pseudomonas aeruginosa Arising by AmpC- and Non-AmpC-Mediated Pathways”

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