68
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Genomic DNA methylation: the mark and its mediators.

      1 ,
      Trends in biochemical sciences
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Methylation of DNA at position five of the cytosine ring occurs at most CpG dinucleotides in the mammalian genome and is essential for embryonic viability. With several of the key proteins now known, it has become possible to approach the biological significance of this epigenetic system through both biochemistry and genetics. As a result, advances have been made in our understanding of the mechanisms by which DNA methylation is targeted to specific regions of the genome and interpreted by methyl-CpG-binding proteins. Recent studies have illuminated the role of DNA methylation in controlling gene expression and have strengthened its links with histone modification and chromatin remodelling.

          Related collections

          Author and article information

          Journal
          Trends Biochem Sci
          Trends in biochemical sciences
          Elsevier BV
          0968-0004
          0968-0004
          Feb 2006
          : 31
          : 2
          Affiliations
          [1 ] Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Mayfield Road, Edinburgh EH9 3JR, UK.
          Article
          S0968-0004(05)00352-X
          10.1016/j.tibs.2005.12.008
          16403636
          a7efa69d-268b-442a-bdb8-f66ff94b8815
          History

          Comments

          Comment on this article