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      Hafnia alvei: A new pathogen in open fractures

      case-report
      * ,
      Trauma Case Reports
      Elsevier
      Hafnia alvei, Open fracture, Forearm fracture, Osteomyelitis

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          Abstract

          Background

          Deep infection following open both bone forearm fractures is a rare complication. Prophylactic antibiotic regimens are targeted at the most common pathogens, which include primarily Staph aureus followed by gram-negative bacteria. Hafnia alvei is an unusual pathogen that is rarely pathogenic in humans and has never been reported as a cause of infection following open fracture.

          Methods

          We present a 12-year-old male with an open forearm fracture who developed a late deep infection. Cultures grew only Hafnia alvei. The patient was treated with debridement, placement of antibiotic beads, and ciprofloxacin.

          Results

          At 6 months following the initial debridement, the patient had no clinical evidence of infection and regained full function of the affected forearm without any residual deficits.

          Conclusions

          This is the first report of deep infection following an open forearm fracture owing to Hafnia alvei, a pathogen rarely responsible for human infection.

          Related collections

          Most cited references13

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          Factors influencing infection rate in open fracture wounds.

          Seventy-seven infections in 1104 open fracture wounds were evaluated to identify those factors that predisposed to infection. Factors could be placed into three categories: (1) increased risk, (2) no effect, and (3) inconclusive. The single most important factor in reducing the infection rate was the early administration of antibiotics that provide antibacterial activity against both gram-positive and gram-negative microorganisms. In this study, surgical debridement was performed on all open fracture wounds.
            • Record: found
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            • Article: not found

            Complications and outcomes of diaphyseal forearm fracture intramedullary nailing: a comparison of pediatric and adolescent age groups.

            Flexible intramedullary nailing (IMN) has become a popular technique for the management of unstable or open forearm fractures. Recent publications have suggested an increased incidence of delayed union and poor outcomes in older children and adolescents. The objective of this study was to review forearm fractures treated with IMN, comparing the rate of complications and outcomes between the 2 age groups. Our hypothesis was that IMN is an effective technique with a similar rate of complications in both age groups.
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              The genus Hafnia: from soup to nuts.

              The genus Hafnia, a member of the family Enterobacteriaceae, consists of gram-negative bacteria that are occasionally implicated in both intestinal and extraintestinal infections in humans. Despite the fact that the genus currently contains only a single species (H. alvei), more extensive phylogenetic depth (two or more species) is apparent based upon DNA relatedness and 16S rRNA gene sequencing studies. Hafnia causes a variety of systemic infections, including septicemia and pneumonia; however, its role as a gastrointestinal pathogen is controversial. Many of the data supporting a role for hafniae as enteric pathogens were incorrectly attributed to this genus rather than to the actual pathogen, Escherichia albertii. There are numerous gaps in our understanding of this genus, including ecologic habitats and population genetics, disease-producing role in animals, phenetic and genetic methods useful in distinguishing genomospecies within the H. alvei complex, and bona fide pathogenicity factors.

                Author and article information

                Contributors
                Journal
                Trauma Case Rep
                Trauma Case Rep
                Trauma Case Reports
                Elsevier
                2352-6440
                18 January 2017
                April 2017
                18 January 2017
                : 8
                : 41-45
                Affiliations
                Dept. of Orthopaedic Surgery, Children's National Medical Center, 111 Michigan Ave., Washington, DC 20010, United States
                Author notes
                [* ]Corresponding author. jody.litrenta@ 123456gmail.com
                Article
                S2352-6440(17)30019-5
                10.1016/j.tcr.2017.01.019
                5883196
                29644313
                a7f16ee9-e5f7-40ad-855a-4a1f78992dca
                © 2017 Published by Elsevier Ltd.

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 3 January 2017
                Categories
                Article

                hafnia alvei,open fracture,forearm fracture,osteomyelitis

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