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      Effect of 5-hydroxytryptamine1 serotonin receptor agonists on noxiously stimulated micturition in cats with chronic spinal cord injury.

      1 , , ,
      The Journal of urology
      Elsevier BV

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          Abstract

          The serotonin 5-hydroxytryptamine(1A/7) receptor agonist (R)-8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) (Sigma) and the 5-hydroxytryptamine(1A/1B/1D) agonist GR-46611 (3-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide) (Tocris Cookson, Ellisville, Missouri) inhibit bladder activity during saline infusion into the bladder of cats with chronic spinal cord injury (saline infused, spinal cord injured cats), suggesting an effect on mechanosensitive bladder afferent C fibers or their targets. We investigated the effects of (R)-8-OH-DPAT and GR-46611 on bladder activity in chronic spinal cord injured cats during infusion of dilute acetic acid into the bladder to stimulate chemosensitive bladder afferent C fibers (acid infused, spinal cord injured cats).

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          Author and article information

          Journal
          J. Urol.
          The Journal of urology
          Elsevier BV
          0022-5347
          0022-5347
          Jun 2007
          : 177
          : 6
          Affiliations
          [1 ] Department of Surgery, Veterans Affairs Medical Center, Duke University Medical Center, Durham, NC 27710, USA.
          Article
          S0022-5347(07)00248-0
          10.1016/j.juro.2007.01.110
          17509363
          a7f6c499-8f1b-4f0e-8235-9f43a8b5ee57
          History

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