Dosing regimens for pancreatic enzyme replacement therapy (PERT) in cystic fibrosis

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:

The primary objective of the review is to compare the efficacy (fat absorption) and effectiveness (nutritional status, lung function and QoL) of different PERT dosing strategies (both dose and administration timings) on dietary malabsorption in all individuals with CF. It will not address co‐administration of proton pump inhibitors as this has been addressed elsewhere.