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      Effect of the social environment on olfaction and social skills in WT and mouse model of autism

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          Abstract

          Autism spectrum disorders are complex, polygenic and heterogenous neurodevelopmental conditions, imposing a substantial economic burden. Genetics are influenced by the environment, specifically the social experience during the critical neurodevelopmental period. Despite efficacy of early behavior interventions targeted specific behaviors in some autistic children, there is no sustainable treatment for the two core symptoms: deficits in social interaction and communication, and stereotyped or restrained behaviors or interests. In this study, we investigated the impact of the social environment on both wild-type (WT) and Shank3 knockout (KO) mice, a mouse model that reproduces core autism-like symptoms. Our findings revealed that WT mice raised in an enriched social environment maintained social interest towards new conspecifics across multiple trials. Additionally, we observed that 2 hours or chronic social isolation induced social deficits or enhanced social interaction and olfactory neuron responses in WT animals, respectively. Notably, chronic social isolation restored both social novelty and olfactory deficits, and normalized self-grooming behavior in Shank3 KO mice. These results novel insights for the implementation of behavioral intervention and inclusive classrooms programs for children with ASD.

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          Author and article information

          Journal
          29 November 2023
          Article
          2402.10212
          a7fd2669-03a2-4a84-961e-8fba47965fe5

          http://arxiv.org/licenses/nonexclusive-distrib/1.0/

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          Custom metadata
          q-bio.NC physics.soc-ph
          ccsd

          General physics,Neurosciences
          General physics, Neurosciences

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