64
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Co-infection rate of HIV, HBV and Syphilis among HCV seropositive identified blood donors in Kathmandu, Nepal

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          HIV, HBV, Syphilis and HCV share common modes of transmission.

          Objective

          The study was aimed to determine the co-infection rate of HIV, HBV and Syphilis among HCV seropositive identified blood donors.

          Methods

          The study was conducted on blood samples screened as HCV seropositive at Nepal Red Cross Society, Central Blood Transfusion Service, Kathmandu, Nepal. HCV seropositive samples were further tested for HIV, HBV and Syphilis.

          Results

          Eight co-infections were observed in 139 HCV seropositives with total co-infection rate of 5.75% (95% CI=2.52-11.03).

          Conclusion

          Co-infection of HIV, HBV and Syphilis with HCV is prevalent in the healthy looking blood donors of Kathmandu, Nepal.

          Related collections

          Most cited references13

          • Record: found
          • Abstract: found
          • Article: not found

          Epidemiology of viral hepatitis and HIV co-infection.

          Worldwide, hepatitis B virus (HBV) accounts for an estimated 370 million chronic infections, hepatitis C virus (HCV) for an estimated 130 million, and HIV for an estimated 40 million. In HIV-infected persons, an estimated 2-4 million have chronic HBV co-infection and 4-5 million have HCV co-infection. HBV, HCV and HIV share common routes of transmission, but they differ in their prevalence by geographic region and the efficiency by which certain types of exposures transmit them. Among HIV-positive persons studied from Western Europe and the USA, chronic HBV infection has been found in 6-14% overall, including 4-6% of heterosexuals, 9-17% of men who have sex with men (MSM), and 7-10% of injection drug users. HCV infection has been found in 25-30% of HIV-positive persons overall; 72-95% of injection drug users, 1-12% of MSM and 9-27% of heterosexuals. The characteristics of HIV infected persons differ according to the co-infecting hepatitis virus, their epidemiologic patterns may change over time, and surveillance systems are needed to monitor their infection patterns in order to ensure that prevention measures are targeted appropriately.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Coinfection of hepatitis B and hepatitis C virus in HIV-infected patients in south India.

            To screen for the co-infection of hepatitis B (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected patients in southern India. Five hundred consecutive HIV infected patients were screened for Hepatitis B Virus (HBsAg and HBV-DNA) and Hepatitis C virus (anti-HCV and HCV-RNA) using commercially available ELISA kits; HBsAg, HBeAg/anti-HBe (Biorad laboratories, USA) and anti-HCV (Murex Diagnostics, UK). The HBV-DNA PCR was performed to detect the surface antigen region (pre S-S). HCV-RNA was detected by RT-PCR for the detection of the constant 5' putative non-coding region of HCV. HBV co-infection was detected in 45/500 (9%) patients and HCV co-infection in 11/500 (2.2%) subjects. Among the 45 co-infected patients only 40 patients could be studied, where the detection rates of HBe was 55% (22/40), antiHBe was 45% (18/40) and HBV-DNA was 56% (23/40). Among 11 HCV co-infected subjects, 6 (54.5%) were anti-HCV and HCV RNA positive, while 3 (27.2%) were positive for anti-HCV alone and 2 (18%) were positive for HCV RNA alone. Since the principal routes for HIV transmission are similar to that followed by the hepatotropic viruses, as a consequence, infections with HBV and HCV are expected in HIV infected patients. Therefore, it would be advisable to screen for these viruses in all the HIV infected individuals and their sexual partners at the earliest.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Transfusion-transmissible infections among blood donors in Kathmandu, Nepal.

              Screening of transfusion-transmissible infections (TTIs) among blood donors can be a cost-effective approach to monitor the prevalence, distribution, and trends of the infections among healthy-looking individuals. The study aimed to determine the seroprevalence of four TTIs, human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis, among blood donors in Kathmandu, Nepal. A total of 21,716 units of blood were tested for the presence of anti-HIV 1/2 IgG/IgM, HBsAg, anti-HCV IgG/IgM, and anti-Treponema pallidum IgG/IgM/IgA using commercial ELISA kits following standard protocols. Statistical analysis was performed using WinPepi Ver 3.8. Seroprevalence of HIV, HBV (HBsAg), HCV and syphilis were observed to be 0.12% (95% CI = 0.08-0.18), 0.47% (95% CI = 0.39-0.57), 0.64% (95% CI = 0.54-0.75) and 0.48% (95% CI = 0.40-0.59) respectively. TTIs were dominant among male blood donors compared to female blood donors. Higher HCV seroprevalence among males compared to females was statistically significant. HIV prevalence was highest among blood donors in the age group 31 to 40 years (P > 0.5). HBV, HCV and syphilis prevalence was highest among blood donors 41 to 50 years age group, 21 to 30 years age group, and 51 to 60 years age group respectively (P 0.05). It is of utmost importance to continue screening donated blood with highly sensitive and specific tests and to counsel donors who are positive to any of the above infections. It is absolutely necessary to avoid the transmission of infection from repeat donors.
                Bookmark

                Author and article information

                Contributors
                Role: Lecturer
                Role: Associate Professor
                Role: Professor
                Role: Director
                Journal
                Infect Ecol Epidemiol
                Infect Ecol Epidemiol
                IEE
                Infection Ecology & Epidemiology
                Co-Action Publishing
                2000-8686
                03 February 2012
                2012
                : 2
                : 10.3402/iee.v2i0.14835
                Affiliations
                [1 ]Department of Microbiology, Gandaki Medical College Teaching Hospital and Research Centre, Kaski, Nepal
                [2 ]Central Department of Microbiology, Tribhuvan University, Kirtipur, Nepal
                [3 ]Faculty of Science and Technology, Pokhara University, Lekhnath, Kaski, Nepal
                [4 ]Central Blood Transfusion Service, Nepal Red Cross Society, Kathmandu, Nepal
                Author notes
                [* ] Ashish Chandra Shrestha, Lecturer, Department of Microbiology, Gandaki Medical College Teaching Hospital and Research Centre, Kaski, Nepal, PO Box-20306, Kathmandu, Nepal. Tel: +977 9841692901. Email: ashishcshrestha@ 123456yahoo.com
                Article
                IEE-2-14835
                10.3402/iee.v2i0.14835
                3426341
                22957133
                a8062db6-0e02-46cf-b14d-0f869d139fc3
                © 2012 Ashish Chandra Shrestha

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 24 November 2011
                : 25 December 2011
                : 10 January 2012
                Categories
                Original Article

                Infectious disease & Microbiology
                hbv,seropositive blood donors,hiv,co-infection,hcv,syphilis
                Infectious disease & Microbiology
                hbv, seropositive blood donors, hiv, co-infection, hcv, syphilis

                Comments

                Comment on this article