5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Calcium channel regulation and presynaptic plasticity.

      1 ,
      Neuron
      Elsevier BV

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Voltage-gated calcium (Ca(2+)) channels initiate release of neurotransmitters at synapses, and regulation of presynaptic Ca(2+) channels has a powerful influence on synaptic strength. Presynaptic Ca(2+) channels form a large signaling complex, which targets synaptic vesicles to Ca(2+) channels for efficient release and mediates Ca(2+) channel regulation. Presynaptic plasticity regulates synaptic function on the timescale of milliseconds to minutes in response to neurotransmitters and the frequency of action potentials. This article reviews the regulation of presynaptic Ca(2+) channels by effectors and regulators of Ca(2+) signaling and describes the emerging evidence for a critical role of Ca(2+) channel regulation in control of neurotransmission and in presynaptic plasticity. Failure of function and regulation of presynaptic Ca(2+) channels leads to migraine, ataxia, and potentially other forms of neurological disease. We propose that presynaptic Ca(2+) channels serve as the regulatory node in a dynamic, multilayered signaling network that exerts short-term control of neurotransmission in response to synaptic activity.

          Related collections

          Author and article information

          Journal
          Neuron
          Neuron
          Elsevier BV
          1097-4199
          0896-6273
          Sep 25 2008
          : 59
          : 6
          Affiliations
          [1 ] Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA. wcatt@u.washington.edu
          Article
          S0896-6273(08)00752-6
          10.1016/j.neuron.2008.09.005
          18817729
          a8078901-6d8a-4629-8489-2b5af5a34d7d

          Comments

          Comment on this article