Age-Dependent Phosphate Homeostasis Is Regulated by a Circulating Factor

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Abstract

To evaluate the age-dependent phosphate homeostasis, we studied the serum inorganic phosphate (P<sub>i</sub>) concentration in 78 recipients, aged 5–25 years, a year after renal transplantation (RT). The significant age-dependent decline of the serum P<sub>i</sub> concentration was observed in recipients (p < 0.0001) as well as in normal children. Our study revealed that a circulating factor may play a central role in the age-dependent change of phosphate regulation in human.

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PHEX gene and hypophosphatemia.

M Drezner (1999)

PHEX gene and hypophosphatemia. X-linked hypophosphatemia (XLH) and tumor-induced osteomalacia (TIO) are diseases that have in common abnormal proximal renal tubular function resulting in increased renal clearance of inorganic phosphorus and hypophosphatemia. The recent discovery of the PHEX gene has provided new insights to these disorders. In this regard, identification of the PHEX gene product as a membrane-bound endopeptidase suggests that the pathophysiologic cascade underlying XLH likely involves inactivation mutations of the gene causing a failure to clear an active hormone, phosphatonin, from the circulation. The presence of this hormone through unknown mechanisms decreases the sodium-dependent phosphate cotransporter in the kidney, resulting in impaired phosphate transport. In contrast, TIO likely evolves secondary to tumor overproduction of the putative phosphatonin, which exerts physiologic function despite efforts to counteract the resultant hypophosphatemia with overproduction of PHEX transcripts that are insufficient to accommodate the enhanced substrate load. These potential pathophysiologic mechanisms for XLH and TIO provide valuable inroads to understanding phosphate homeostasis, as well as vitamin D metabolism, bone mineralization, and calcium metabolism.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 2002

Publication date (Print): October 2002

Publication date (Electronic): 18 October 2002

Volume: 92

Issue: 4

Pages: 931-932

Affiliations

^aDepartment of Pediatric Nephrology, Tokyo Women’s Medical University, Tokyo, and ^bDepartment of Medicine, St. Luke’s International Hospital, Tokyo, Japan

Article

Publisher ID: 65447 Other ID: Nephron 2002;92:931–932

DOI: 10.1159/000065447

PubMed ID: 12399643

SO-VID: a809e5c5-ea18-446f-b95b-34fff32dd137

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Age-Dependent Phosphate Homeostasis Is Regulated by a Circulating Factor

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Karger: Nephrology

Most cited references 1

PHEX gene and hypophosphatemia.

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