3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Ultrasonically encoded photoacoustic flowgraphy in biological tissue.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Blood flow speed is an important functional parameter. Doppler ultrasound flowmetry lacks sufficient sensitivity to slow blood flow (several to tens of millimeters per second) in deep tissue. To address this challenge, we developed ultrasonically encoded photoacoustic flowgraphy combining ultrasonic thermal tagging with photoacoustic imaging. Focused ultrasound generates a confined heat source in acoustically absorptive fluid. Thermal waves propagate with the flow and are directly visualized in pseudo color using photoacoustic computed tomography. The Doppler shift is employed to calculate the flow speed. This method requires only acoustic and optical absorption, and thus is applicable to continuous fluid. A blood flow speed as low as 0.24  mm·s(-1)} was successfully measured. Deep blood flow imaging was experimentally demonstrated under 5-mm-thick chicken breast tissue.

          Related collections

          Author and article information

          Journal
          Phys. Rev. Lett.
          Physical review letters
          1079-7114
          0031-9007
          Nov 15 2013
          : 111
          : 20
          Affiliations
          [1 ] Department of Biomedical Engineering, Optical Imaging Laboratory, Washington University in Saint Louis Campus Box 1097, One Brookings Drive, Saint Louis, Missouri 63130-4899, USA.
          Article
          NIHMS542226
          10.1103/PhysRevLett.111.204301
          24289689
          a8108641-ea4d-4437-b063-b3cb1cc8bb5c
          History

          Comments

          Comment on this article