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      PET-MRI: a review of challenges and solutions in the development of integrated multimodality imaging

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          Abstract

          The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) has been an ongoing research topic for the last 20 years. This paper gives an overview of the different developments and the technical problems associated with combining PET and MRI in one system. After explaining the different detector concepts for integrating PET-MRI and minimising interference the limitations and advantages of different solutions for the detector and system are described for preclinical and clinical imaging systems. The different integrated PET-MRI systems are described in detail. Besides detector concepts and system integration the challenges and proposed solutions for attenuation correction and the potential for motion correction and resolution recovery are also discussed in this topical review.

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          Most cited references 6

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          Simple modification of a spin echo imaging pulse sequence generates useful spectroscopic information at 0.35 T. New images are produced that show water only, fat only, and the difference between water and fat intensity. Imaging speed, spatial resolution, and signal-to-noise ratio are comparable with ordinary imaging. The method provides new parameters for tissue characterization and improved contrast between some organs.
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            MicroPET: a high resolution PET scanner for imaging small animals

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              Superconducting open-configuration MR imaging system for image-guided therapy.

              To develop a superconducting magnetic resonance (MR) imager that provides direct access to the patient and permits interactive MR-guided interventional procedures. A 0.5-T superconducting magnet that allows a region of vertical access to the patient was designed and constructed. This magnet was integrated with newly designed shielded gradient coils, flexible surface coils, and nonmagnetic displays and with position-monitoring probes and device-tracking instrumentation. The magnet homogeneity was 12.3 ppm, and the gradient field was linear to within 1% over an imaging region 30 cm in diameter. The signal-to-noise ratio was 10% higher than in a comparable 0.5-T superconducting imager. Images were obtained in several anatomic regions with use of routine pulse sequences. Interactive image plane selection and near real-time imaging, with use of fast gradient-recalled echo sequences, were demonstrated at a rate of one image every 1.5 seconds. MR-guided interventional procedures can be performed with full patient access with use of an open-configuration, superconducting MR magnet with near real-time imaging and interactive image plane control.
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                Author and article information

                Journal
                2015-10-16
                1510.04875 10.1088/0031-9155/60/4/R115

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

                Custom metadata
                41 pages, topical review on PET-MRI. Physics in medicine and biology, 2015
                physics.med-ph

                Medical physics

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