Efficacy of α2-Agonists for Sedation in Pediatric Critical Care: A Systematic Review.

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Abstract

Children in PICUs normally require analgesics and sedatives to maintain comfort, safety, and cooperation with interventions. α2-agonists (clonidine and dexmedetomidine) have been described as adjunctive (or alternative) sedative agents alongside opioids and benzodiazepines. This systematic review aimed to determine whether α2-agonists were effective in maintaining patients at a target sedation score over time compared with a comparator group. We also aimed to determine whether concurrent use of α2-agonists provided opioid-sparing effects.

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Journal

Journal ID (iso-abbrev): Pediatr Crit Care Med

Title: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN: 1529-7535

ISSN (Print): 1529-7535

Publication date (Electronic): Feb 2016

Volume: 17

Issue: 2

Affiliations

[1 ] 1School of Pharmacy, Royal College of Surgeons in Ireland, Dublin, Ireland. 2Paediatric Intensive Care Unit, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland. 3Paediatric Intensive Care Unit, Children's University Hospital, Temple Street, Dublin, Ireland.

Article

DOI: 10.1097/PCC.0000000000000599

PubMed ID: 26704469

SO-VID: a8328a6e-fe0d-4633-b318-c6add55411f7

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