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      Identifying the perfusion deficit in acute stroke with resting-state functional magnetic resonance imaging.

      Annals of Neurology

      Adult, Aged, Aged, 80 and over, Cerebrovascular Circulation, physiology, Female, Humans, Magnetic Resonance Imaging, methods, Male, Middle Aged, Rest, Stroke, diagnosis, physiopathology

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          Abstract

          Temporal delay in blood oxygenation level-dependent (BOLD) signals may be sensitive to perfusion deficits in acute stroke. Resting-state functional magnetic resonance imaging (rsfMRI) was added to a standard stroke MRI protocol. We calculated the time delay between the BOLD signal at each voxel and the whole-brain signal using time-lagged correlation and compared the results to mean transit time derived using bolus tracking. In all 11 patients, areas exhibiting significant delay in BOLD signal corresponded to areas of hypoperfusion identified by contrast-based perfusion MRI. Time delay analysis of rsfMRI provides information comparable to that of conventional perfusion MRI without the need for contrast agents. Copyright © 2012 American Neurological Association.

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          Journal
          23378326
          10.1002/ana.23763

          Comments

          The first study to show the use of resting-state functional MRI (rsfMRI) for assessing blood flow.

          Study sample consisted of 11 acute stroke patients. 

          Compared time shift analysis of rsfMRI data to perfusion maps (mean transit time - MTT) derived from dynamic susceptibility contrast MRI (DSC-MRA). 

          Analysis was mostly qualitative (visual), with spatial overlap of the perfusion lesions derived from the two methods also being calculated. 

           

          2020-03-31 08:27 UTC
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