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      Escape from Drug-Induced Constriction of Isolated Arterial Segments from Various Vascular Beds

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      Journal of Vascular Research

      S. Karger AG

      Vascular smooth muscle, Vasoconstrictor escape, Mesenteric arteries, Noradrenaline

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          Abstract

          The tension response to prolonged noradrenaline exposure was studied in arterial segments from the mesenteric, splenic, hepatic, renal, and femoral vasculatures of the cat. Vessel segments responded to noradrenaline superfusion with an initial, rapid increase intension, which subsequently ‘escaped’ toward control levels during continued noradrenaline exposure. This escape was observed in arteries from all the vascular beds studied, but most frequently in the hepatic, mesenteric, and splenic vessels. Additionally, mesenteric vessels escaped in response to vasopressin, adrenaline, and phenylephrine. Vasoconstrictor escape in the isolated arterial segments closely corresponds with reported in vivo blood flow responses of the respective vasculatures and the mechanism of vasoconstrictor escape is discussed.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1972
          1972
          18 September 2008
          : 9
          : 1
          : 27-33
          Affiliations
          Department of Physiology, UCLA School of Medicine, Los Angeles, Calif.
          Article
          157912 Angiologica 1972;9:27–33
          10.1159/000157912
          © 1972 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Paper

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