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      Moléstia de Creutzfeldt-Jakob: estudo clínico, histopatológico e eletromicroscópico de um caso Translated title: Creutzfeldt-Jakob disease: a case report

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          Abstract

          É apresentado o caso de paciente de 53 anos de idade com quadro de rebaixamento mental e comprometimento piramidal, com evolução progressiva até mutismo acinético em 6 meses de evolução. Um pneumencefalograma mostrou aumento simétrico do sistema ventricular. Uma biópsia cerebral permitiu encontrar alterações neuronais, gliose e estado espongioso que permitiram classificar o caso como de moléstia de Creutzfeldt-Jakob. São discutidos os achados eletromicroscópicos.

          Translated abstract

          The case of a patient 53 years old that had a picture of cortical impairment and pyramidal disfunction, leading in 6 months to acinetic mutism is reported. The histopathology lead to the diagnostic of Creutzeldt-Jakob disease, with neuronal loss, gliosis and status spongiosus. The electron-microscopic examination showed that the status spongiosus was due to cellular processes, some having vesicular bodies sugestive of pre-synaptic vesicles.

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          Most cited references 13

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          EXPERIMENTAL KURU ENCEPHALOPATHY IN CHIMPANZEES AND SPIDER MONKEYS

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            Effects of intracerebral injection of ouabain on the fine structure of rat cerebral cortex

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              Subacute spongiform encephalopathy

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                Author and article information

                Affiliations
                [1 ] Hospital do Servidor Público Estadual Francisco Morato de Oliveira Brazil
                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                anp
                Arquivos de Neuro-Psiquiatria
                Arq. Neuro-Psiquiatr.
                Academia Brasileira de Neurologia - ABNEURO (São Paulo )
                1678-4227
                September 1977
                : 35
                : 3
                : 270-276
                S0004-282X1977000300011
                10.1590/S0004-282X1977000300011

                http://creativecommons.org/licenses/by/4.0/

                Product
                Product Information: SciELO Brazil
                Categories
                NEUROSCIENCES
                PSYCHIATRY

                Neurosciences, Clinical Psychology & Psychiatry

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