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Moléstia de Creutzfeldt-Jakob: estudo clínico, histopatológico e eletromicroscópico de um caso Translated title: Creutzfeldt-Jakob disease: a case report

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      Abstract

      É apresentado o caso de paciente de 53 anos de idade com quadro de rebaixamento mental e comprometimento piramidal, com evolução progressiva até mutismo acinético em 6 meses de evolução. Um pneumencefalograma mostrou aumento simétrico do sistema ventricular. Uma biópsia cerebral permitiu encontrar alterações neuronais, gliose e estado espongioso que permitiram classificar o caso como de moléstia de Creutzfeldt-Jakob. São discutidos os achados eletromicroscópicos.

      Translated abstract

      The case of a patient 53 years old that had a picture of cortical impairment and pyramidal disfunction, leading in 6 months to acinetic mutism is reported. The histopathology lead to the diagnostic of Creutzeldt-Jakob disease, with neuronal loss, gliosis and status spongiosus. The electron-microscopic examination showed that the status spongiosus was due to cellular processes, some having vesicular bodies sugestive of pre-synaptic vesicles.

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      Most cited references 13

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      EXPERIMENTAL KURU ENCEPHALOPATHY IN CHIMPANZEES AND SPIDER MONKEYS

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        Subacute spongiform encephalopathy

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          Creutzfeldt-Jakob disease: further similarities with kuru

           J Adams,  E Beck,  H Shenkin (1974)
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            Author and article information

            Affiliations
            [1 ] Hospital do Servidor Público Estadual Francisco Morato de Oliveira Brazil
            Contributors
            Role: ND
            Role: ND
            Role: ND
            Role: ND
            Journal
            anp
            Arquivos de Neuro-Psiquiatria
            Arq. Neuro-Psiquiatr.
            Academia Brasileira de Neurologia - ABNEURO (São Paulo )
            1678-4227
            September 1977
            : 35
            : 3
            : 270-276
            S0004-282X1977000300011
            10.1590/S0004-282X1977000300011

            http://creativecommons.org/licenses/by/4.0/

            Product
            Product Information: SciELO Brazil
            Categories
            NEUROSCIENCES
            PSYCHIATRY

            Neurosciences, Clinical Psychology & Psychiatry

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