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Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum.
David J Pombo
1 ,
Gregor Lawrence ,
Chakrit Hirunpetcharat ,
Christine Rzepczyk ,
Michelle Bryden ,
Nicole Cloonan ,
Karen Anderson ,
Yuvadee Mahakunkijcharoen ,
Laura B Martin ,
Danny Wilson ,
Salenna Elliott ,
Suzanne Elliott ,
Damon P Eisen ,
J Brice Weinberg ,
Allan Saul ,
Michael F Good
Aug 24 2002
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Abstract
The ability of T cells, acting independently of antibodies, to control malaria parasite growth in people has not been defined. If such was shown to be effective, an additional vaccine strategy could be pursued. Our aim was to ascertain whether or not development of cell-mediated immunity to Plasmodium falciparum blood-stage infection could be induced in human beings by exposure to malaria parasites in very low density.