Leo Y Lee:
ORCID: https://orcid.org/0000-0001-6704-1235
Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Jie Zhou: Role: Formal analysisRole: InvestigationRole: MethodologyRole: Writing – original
draftRole: Writing – review & editing
Paulina Koszalka: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Rebecca Frise:
ORCID: https://orcid.org/0000-0002-5522-623X
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Rubaiyea Farrukee:
ORCID: https://orcid.org/0000-0001-9023-246X
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Keiko Baba:
ORCID: https://orcid.org/0000-0001-8463-2897
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Shahjahan Miah:
ORCID: https://orcid.org/0000-0001-7810-3497
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Takao Shishido:
ORCID: https://orcid.org/0000-0002-2549-0945
Role: MethodologyRole: SupervisionRole: Writing – review & editing
Monica Galiano:
ORCID: https://orcid.org/0000-0001-7046-3762
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Takashi Hashimoto:
ORCID: https://orcid.org/0000-0002-6171-2787
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Shinya Omoto:
ORCID: https://orcid.org/0000-0002-2730-3912
Role: MethodologyRole: SupervisionRole: Writing – review & editing
Takeki Uehara:
ORCID: https://orcid.org/0000-0002-5853-9426
Role: SupervisionRole: Writing – review & editing
Edin J. Mifsud: Role: InvestigationRole: MethodologyRole: Writing – review & editing
Neil Collinson:
ORCID: https://orcid.org/0000-0001-6602-7845
Role: ConceptualizationRole: Funding acquisitionRole: Writing – review & editing
Klaus Kuhlbusch: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Barry Clinch: Role: ConceptualizationRole: Writing – review & editing
Steffen Wildum:
ORCID: https://orcid.org/0000-0001-9779-5740
Role: ConceptualizationRole: SupervisionRole: Writing – original draftRole: Writing
– review & editing
Wendy S. Barclay: Role: ConceptualizationRole: SupervisionRole: Writing – original draftRole: Writing
– review & editing
Aeron C. Hurt:
ORCID: https://orcid.org/0000-0001-9731-3481
Role: ConceptualizationRole: MethodologyRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Anice C. Lowen: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
6
May
2021
Publication date Collection:
May
2021
Volume: 17
Issue: 5
Electronic Location Identifier: e1009527
Affiliations
[1
]
WHO Collaborating Centre for Reference and Research on Influenza, at the Peter Doherty
Institute for Infection and Immunity, Melbourne, Australia
[2
]
Department of Infectious Disease, Imperial College London, London, United Kingdom
[3
]
Biomedicine Discovery Institute & Department of Microbiology, Monash University, Victoria,
Australia
[4
]
Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty
Institute for Infection and Immunity, Parkville, Australia
[5
]
Shionogi & Co., Ltd, Osaka, Japan
[6
]
Public Health England, London, United Kingdom
[7
]
Francis Crick Institute, London, United Kingdom
[8
]
Roche Products Ltd, Welwyn Garden City, United Kingdom
[9
]
F. Hoffmann-La Roche Ltd, Basel, Switzerland
Emory University School of Medicine, UNITED STATES
Author notes
I have read the journal’s policy and the authors of this manuscript have the following
competing interests: • Keiko Baba, Takashi Hashimoto, Shinya Omoto, Takao Shishido
and Takeki Uehara are employees of Shionogi & Co. • Klaus Kuhlbusch, Steffen Wildum
and Aeron C Hurt are employees of F. Hoffmann-La Roche. • Neil Collinson and Barry
Clinch are employees of Roche Products Ltd. • Wendy Barclay has received honoraria
from Roche, Sanofi Pasteur and Seqirus. • Leo YY Lee has received honoraria from Roche.
• Paulina Koszalka, Jie Zhou, Rubaiyea Farrukee, Rebecca Frise, Edin Mifsud, Monica
Galiano and Shahjahan Miah have nothing to disclose.
[¤]
Current address: Department of Microbiology and Immunology, University of Melbourne,
at the Peter Doherty Institute for Infection and Immunity, Parkville, Australia
Author information
Article
Publisher ID:
PPATHOGENS-D-20-02266
DOI: 10.1371/journal.ppat.1009527
PMC ID: 8130947
PubMed ID: 33956888
SO-VID: a8525592-45fd-4af6-a2f7-e6b08897385c
Copyright © © 2021 Lee et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100007013, F. Hoffmann-La Roche;
Funded by: funder-id http://dx.doi.org/10.13039/501100005612, Shionogi;
Funded by: Australian Government, Department of Health
Award ID: support to Melbourne WHO Collaborating Centre for Reference and Research on Influenza
This work was funded by F. Hoffmann-La Roche (
https://www.roche.com/) and Shionogi & Co. Ltd (
https://www.shionogi.com/eu/en/) who both played a role in the study design, data collection and analysis, decision
to publish and preparation of the manuscript. The Melbourne WHO Collaborating Centre
for Reference and Research on Influenza is supported by the Australian Government
Department of Health, who had no role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Ferrets
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
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Vertebrates
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Amniotes
Subject:
Mammals
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Ferrets
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
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Influenza Viruses
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza Viruses
Subject:
Biology and Life Sciences
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Microbiology
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Virology
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Viral Transmission and Infection
Subject:
Medicine and Health Sciences
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Medical Conditions
Subject:
Infectious Diseases
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Viral Diseases
Subject:
Influenza
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Replication
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Microbial Mutation
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Respiratory Infections
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Respiratory Disorders
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Respiratory Infections
Subject:
Medicine and Health Sciences
Subject:
Pulmonology
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Respiratory Disorders
Subject:
Respiratory Infections