13
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Multiple independent origins of Shigella clones of Escherichia coli and convergent evolution of many of their characteristics.

      Proceedings of the National Academy of Sciences of the United States of America
      Base Sequence, Chromosomes, Bacterial, DNA, Bacterial, Escherichia coli, genetics, Evolution, Molecular, Molecular Sequence Data, Phylogeny, Sequence Homology, Nucleic Acid, Shigella

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The evolutionary relationships of 46 Shigella strains representing each of the serotypes belonging to the four traditional Shigella species (subgroups), Dysenteriae, Flexneri, Boydii, and Sonnei, were determined by sequencing of eight housekeeping genes in four regions of the chromosome. Analysis revealed a very similar evolutionary pattern for each region. Three clusters of strains were identified, each including strains from different subgroups. Cluster 1 contains the majority of Boydii and Dysenteriae strains (B1-4, B6, B8, B10, B14, and B18; and D3-7, D9, and D11-13) plus Flexneri 6 and 6A. Cluster 2 contains seven Boydii strains (B5, B7, B9, B11, B15, B16, and B17) and Dysenteriae 2. Cluster 3 contains one Boydii strain (B12) and the Flexneri serotypes 1-5 strains. Sonnei and three Dysenteriae strains (D1, D8, and D10) are outside of the three main clusters but, nonetheless, are clearly within Escherichia coli. Boydii 13 was found to be distantly related to E. coli. Shigella strains, like the other pathogenic forms of E. coli, do not have a single evolutionary origin, indicating convergent evolution of Shigella phenotypic properties. We estimate the three main Shigella clusters to have evolved within the last 35,000 to 270,000 years, suggesting that shigellosis was one of the early infectious diseases of humans.

          Related collections

          Author and article information

          Journal
          10954745
          27065
          10.1073/pnas.180094797

          Chemistry
          Base Sequence,Chromosomes, Bacterial,DNA, Bacterial,Escherichia coli,genetics,Evolution, Molecular,Molecular Sequence Data,Phylogeny,Sequence Homology, Nucleic Acid,Shigella

          Comments

          Comment on this article