31
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Diabetic cardiomyopathy: the search for a unifying hypothesis.

      Circulation Research

      Animals, Cardiomyopathies, etiology, Coronary Circulation, Diabetes Complications, pathology, physiopathology, Diabetes Mellitus, Type 1, complications, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, blood, Humans, Hyperglycemia, Hyperinsulinism, Hypertrophy, Left Ventricular, Insulin Resistance, Phosphatidylinositol 3-Kinases, physiology, Proto-Oncogene Proteins c-akt, Ventricular Dysfunction, Left

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart disease, less is known as to whether diabetes causes an altered cardiac phenotype independent of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ventricular hypertrophy, and alterations in the coronary microcirculation have all been observed, although not consistently, in diabetic cardiomyopathy and are not fully explained by the cellular effects of hyperglycemia alone. The recent recognition that diabetes involves more than abnormal glucose homeostasis provides important new opportunities to examine and understand the impact of complex metabolic disturbances on cardiac structure and function.

          Related collections

          Author and article information

          Journal
          16543510
          10.1161/01.RES.0000207406.94146.c2

          Comments

          Comment on this article