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      Resting-state oscillatory activity in autism spectrum disorders.

      Journal of Autism and Developmental Disorders

      Male, Magnetoencephalography, Humans, Female, physiopathology, Child Development Disorders, Pervasive, Child, Cerebral Cortex, physiology, Brain Waves, Brain Mapping, Biological Clocks, Adolescent

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          Abstract

          Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1-4 Hz), theta (4-8 Hz), alpha (8-12 Hz), and high frequency (20-120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.

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          Author and article information

          Journal
          22207057
          3638261
          10.1007/s10803-011-1431-6

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