A 59-year-old woman presented with a minimally itchy and tender plaque on the dorsum
of the left hand since last 4 years. According to the patient it started as a small
papule following blood collection at the site and gradually increased in size. She
was a known diabetic; controlled on insulin for the past 15 years. She had used a
topical antibiotic intermittently with no relief. On clinical examination, there was
a well-defined erythematous plaque with hyperpigmented borders and overlying crust
[Figure 1]. Rest of the dermatological and systemic examination of the patient was
normal.
Figure 1
Well-defined erythematous plaque with hyperpigmented borders and overlying crust present
on the dorsum of the left hand
A skin biopsy was performed. The histopathology showed epidermal acanthosis with focal
ulceration. There were atypical pleomorphic hyperchromatic keratinocytes spanning
the entire epidermis with loss of epidermal differentiation and polarity. Vacuolization
and individual cell keratinization was appreciated [Figures 2 and 3]. Diagnosis of
Bowen's disease (BD) was made.
Figure 2
Hematoxylin and eosin, ×4-epidermal acanthosis with focal ulceration with inflammatory
infiltrate in the upper dermis
Figure 3
Hematoxylin and eosin, ×40 - pleomorphic, hyperchromatic, atypical keratinocytes spanning
the entire epidermis with prominent vacuolization. Loss of differentiation and polarity
seen
DISCUSSION
BD was first described by an American Dermatologist John T. Bowen in 1912. It is a
squamous cell carcinoma in situ with potential for significant lateral spread.
It can affect the skin and mucous membranes. The involvement of sun-exposed sites
is more common in the whites, whereas that of the unexposed sites is more common in
the pigmented skin.[1] It is more common on the head, neck, and extremities in men
and lower limbs and cheeks in females. It ranges from very few millimeters to several
centimeters in diameter. Lesions are usually solitary, but multiple lesions are seen
in 10-20% of patients.
Significant sun exposure, ionizing radiation, arsenic exposure,[2] immunosuppression,[3]
and certain types of human papillomavirus[4] are predisposing factors for BD. Genetic
factors, trauma, chemical carcinogens, and X-ray radiation are other factors implicated
in the pathogenesis.
Patients usually present with an asymptomatic slowly enlarging erythematous scaly
patch or plaque. Histopathology shows full-thickness anaplasia of the epidermis with
loss of normal maturation, although the basement membrane remains intact. Parakeratosis
and hyperkeratosis, acanthosis with complete disorganization of the epidermal structure
is present. Throughout the epidermis are numerous, atypical, pleomorphic hyperchromatic
keratinocytes producing the windblown appearance. These cells are sometimes vacuolated
and have a pale-staining cytoplasm. Loss of maturation and polarity of the cells,
numerous mitotic figures, individually keratinized cells, multinucleated cells and
atypical cells are seen throughout the pilosebaceous unit, within the acrotrichium,
follicular infundibula, and sebaceous glands.
The chances of development of squamous cell carcinoma (SCC) in a case of BD is 3%-5%
and there are 33% chances of metastasis from a case of SCC that has evolved from BD.
Therapy is guided by size and location of BD in addition to individual patient characteristics,
such as age and healing capacity. Surgical excision is generally regarded as the treatment
of choice for most BD lesions, if the lesions size and location permit such a procedure.
Mohs micrographic surgery, electrodesiccation and curettage, cryosurgery, topical
chemotherapy with 5-fluorouracil, topical immune response modifiers, such as imiquimod,
laser therapy, radiotherapy, and photodynamic therapy are the known modalities of
treatment.[5]