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      Inhibition of the GTPase dynamin or actin depolymerisation initiates outward plasma membrane tubulation/vesiculation (cytoneme formation) in neutrophils.

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          Abstract

          In a previous study, we demonstrated that human neutrophils can develop membrane tubulovesicular extensions (TVEs) that are 160-250 nm in width and several micrometres long. These extensions, or cytonemes, are capable of establishing long-range contacts with other cells or bacteria. Cytonemes consist of membrane tubules and vesicles of a uniform diameter aligned in a row. The mechanism of membrane tubulation/vesiculation to form cytonemes remains unknown. Upon endocytosis, the GTPase dynamin and an intact actin cytoskeleton are required for endocytic vesicles scission from the plasma membrane.

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          Author and article information

          Journal
          Biol. Cell
          Biology of the cell
          Wiley-Blackwell
          1768-322X
          0248-4900
          May 2015
          : 107
          : 5
          Affiliations
          [1 ] A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.
          Article
          10.1111/boc.201400063
          25655190
          a89f398a-bb71-4db2-8447-5b345294a13c
          History

          dynamin,dynasore,membrane tubular invaginations,cytonemes,actin depolymerisation

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