CD39+ regulatory T cells attenuate allergic airway inflammation.

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Abstract

The suppressive mechanism of regulatory T cells (Tregs) has remained incompletely clarified. Recent studies found that CD39 expressed by Tregs may participate in the immunoregulatory role of Tregs. CD39-induced ATP hydrolysis and/or adenosine generation contribute to the suppressive mechanism of Tregs. Previous studies suggested that ATP is involved in allergic airway inflammation by acting on type 2 purinergic (P2) receptors, but the role of CD39 and CD39(+) Tregs in allergic airway inflammation has not been elaborated.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin. Exp. Allergy

Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Publisher: Wiley-Blackwell

ISSN (Electronic): 1365-2222

ISSN (Print): 0954-7894

Publication date (Electronic): Jun 2015

Volume: 45

Issue: 6

Affiliations

[1 ] Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.

[2 ] Department of Medicine, Transplant Institute and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Article

DOI: 10.1111/cea.12521

PubMed ID: 25728362

SO-VID: a8aceb6b-4d5e-4791-8b21-bf2e9cbf967c

History

Keywords: ATP,CD39,adenosine,allergic asthma,regulatory T cells

Data availability:

Keywords: ATP, CD39, adenosine, allergic asthma, regulatory T cells

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