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      CD39+ regulatory T cells attenuate allergic airway inflammation.

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          Abstract

          The suppressive mechanism of regulatory T cells (Tregs) has remained incompletely clarified. Recent studies found that CD39 expressed by Tregs may participate in the immunoregulatory role of Tregs. CD39-induced ATP hydrolysis and/or adenosine generation contribute to the suppressive mechanism of Tregs. Previous studies suggested that ATP is involved in allergic airway inflammation by acting on type 2 purinergic (P2) receptors, but the role of CD39 and CD39(+) Tregs in allergic airway inflammation has not been elaborated.

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          Author and article information

          Journal
          Clin. Exp. Allergy
          Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
          Wiley-Blackwell
          1365-2222
          0954-7894
          Jun 2015
          : 45
          : 6
          Affiliations
          [1 ] Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
          [2 ] Department of Medicine, Transplant Institute and Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
          Article
          10.1111/cea.12521
          25728362

          ATP, CD39, adenosine, allergic asthma, regulatory T cells

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