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      Polymicrobial synergy and dysbiosis in inflammatory disease.

      1 , 2
      Trends in molecular medicine

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          Abstract

          Uncontrolled inflammation of the periodontal area may arise when complex microbial communities transition from a commensal to a pathogenic entity. Communication among constituent species leads to polymicrobial synergy between metabolically compatible organisms that acquire functional specialization within the developing community. Keystone pathogens, even at low abundance, elevate community virulence, and the resulting dysbiotic community targets specific aspects of host immunity to further disable immune surveillance while promoting an overall inflammatory response. Inflammophilic organisms benefit from proteinaceous substrates derived from inflammatory tissue breakdown. Inflammation and dysbiosis reinforce each other, and the escalating environmental changes further select for a pathobiotic community. We have synthesized the polymicrobial synergy and dysbiotic components of the process into a new model for inflammatory diseases.

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          Author and article information

          Journal
          Trends Mol Med
          Trends in molecular medicine
          1471-499X
          1471-4914
          Mar 2015
          : 21
          : 3
          Affiliations
          [1 ] Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, KY, USA. Electronic address: rich.lamont@louisville.edu.
          [2 ] Department of Microbiology, Penn Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: geoh@upenn.edu.
          Article
          S1471-4914(14)00196-8 NIHMS644017
          10.1016/j.molmed.2014.11.004
          25498392
          a8bf0214-c137-48af-bc76-64467fc2333f
          Copyright © 2014 Elsevier Ltd. All rights reserved.
          History

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