Association of NLRP3 and CARD8 genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population.

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Abstract

An elevated interleukin (IL)-1β response in peripheral blood mononuclear cells (PBMCs) has been observed in systemic juvenile idiopathic arthritis (sJIA), suggesting a role for inflammasomes in the pathogenesis of JIA. We aimed to determine whether genetic polymorphisms of the NLRP3 inflammasome components confer risk for oligoarticular and polyarticular JIA in a Taiwanese population.

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Journal

Journal ID (iso-abbrev): Scand. J. Rheumatol.

Title: Scandinavian journal of rheumatology

ISSN (Electronic): 1502-7732

ISSN (Print): 0300-9742

Publication date (Electronic): 2014

Volume: 43

Issue: 2

Affiliations

[1 ] Departments of Paediatrics, National Taiwan University Hospital , Taipei , Taiwan.

Article

DOI: 10.3109/03009742.2013.834962

PubMed ID: 24295199

SO-VID: a8c76cdd-dc89-4227-b2c1-b25ad5e63277

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