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      The effects of carbenoxolone on spatial learning in the Morris water maze task in rats.

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          Abstract

          High-frequency oscillations (ripples) are proposed to be involved in memory consolidation. Ripple oscillations persist in the absence of chemical synaptic transmission and inhibitors of gapjunctions were shown to block high-frequency oscillations in hippocampal slices. In this study we investigated the effects of carbenoxolone, as a gap-junction blocker, on spatial learning in the rat. Cognitive performance was assessed using the Morris water maze (MWM).

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          Author and article information

          Journal
          Med. Sci. Monit.
          Medical science monitor : international medical journal of experimental and clinical research
          1234-1010
          1234-1010
          Mar 2005
          : 11
          : 3
          Affiliations
          [1 ] Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I R Iran. hosseinzadehh@mums.ac.ir
          Article
          5659
          15735560

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