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      Dissecting spinal cord regeneration

      Nature
      Springer Nature America, Inc

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          Abstract

          The inability to recover functions lost after severe spinal cord injury has been recognized for millennia and was first attributed to a failure of spinal cord neural regeneration over 100 years ago. The last forty years have seen intense research into achieving such regeneration, but in spite of conceptual advances and many reports announcing successful interventions, progress has been slow and often controversial. Here, I examine consequential advances and setbacks, and critically consider assumptions underlying certain approaches. I argue that expanding mechanistic knowledge about multiple forms of neural regeneration, why they fail and how they can restore function will resolve conceptual contentions and push the field forward.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Nature America, Inc
          0028-0836
          1476-4687
          May 2018
          May 16 2018
          May 2018
          : 557
          : 7705
          : 343-350
          Article
          10.1038/s41586-018-0068-4
          29769671
          a8fa45a9-d99d-4254-8d70-0ed0312b8123
          © 2018

          http://www.springer.com/tdm

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