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      Ascorbic acid supplementation ameliorates testicular hormonal signaling, sperm production and oxidative stress in male rats exposed to rosuvastatin during pre-puberty.

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          Abstract

          Dyslipidemias are occurring earlier in the population due to the augmentation of obesity. Rosuvastatin reduces cholesterol and triglycerides; however, previous studies have shown that it may affect male reproduction. Ascorbic acid (AA), an antioxidant compound, plays a protective role in the male reproductive system. This study aimed to evaluate whether pre-pubertal exposure to rosuvastatin may impair testicular structure and antioxidant status in male rats and if supplementation with AA may alleviate these damages. Male rats were randomly divided into six experimental groups (n = 10) on postnatal day (PND) 23 and received the different treatments by gavage from PND 23 to 53. The experimental groups received vehicle (saline solution 0.9%), 3 or 10 mg/kg/day of rosuvastatin diluted in saline solution 0.9%, supplementation with 150 mg/day of AA, 3 mg/kg/day of rosuvastatin in association with 150 mg/day of AA or 10 mg/kg/day of rosuvastatin associated with 150 mg/day of AA. Testicular parameters were assessed on PND 53 and 110. There were diminished androgen receptors staining in the Sertoli cells and increased germ cell death in rosuvastatin-exposed groups, in both periods. Spermatids showed lower estrogen alpha-receptors staining in the group exposed to 10 mg of statin at adulthood. There were androgen depletion and increased lipid peroxidation and catalase activity in statin-exposed groups. Rosuvastatin exposure during pre-puberty impaired testicular structure, steroid receptor distribution and increased oxidative stress; however, AA was able to ameliorate the impairment provoked by statin exposure.

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          Author and article information

          Journal
          J Appl Toxicol
          Journal of applied toxicology : JAT
          Wiley
          1099-1263
          0260-437X
          February 2019
          : 39
          : 2
          Affiliations
          [1 ] Graduate Program in Cell and Structural Biology, Institute of Biology, State University of Campinas - UNICAMP, Campinas, Brazil.
          [2 ] Department of Morphology, São Paulo State University (Unesp), Institute of Biosciences, Botucatu, Brazil.
          [3 ] Department of Clinical Analyses, Toxicology and Food Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, Brazil.
          [4 ] Department of Morphology, Physiology and Basic Pathology, School of Dentistry of Ribeirão Preto, USP-University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
          Article
          10.1002/jat.3720
          30240002
          a9135712-8f70-4279-9687-fd2bd766ab13
          © 2018 John Wiley & Sons, Ltd.
          History

          toxicology,vitamin C,testis,statin,male reproduction
          toxicology, vitamin C, testis, statin, male reproduction

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