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      Rho small G protein and cytoskeletal control.

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          Abstract

          The Rho family belongs to the Ras-related small GTP-binding protein (G protein) superfamily and regulates various cell functions in which the actomyosin system is involved, including cell morphology, membrane ruffling, cell motility, cell aggregation, cytokinesis, smooth muscle contraction, and yeast budding. Three GDP/GTP exchange proteins (GEPs), named Smg GDS, Dbl, and Rho GDI, and two GTPase activating proteins (GAPs), named Rho GAP and p190 associated with Ras GAP, have been identified. The Rho activity is likely to be regulated by protein kinase C which is linked through phospholipase C to the tyrosine kinase-type membrane receptors and the heterotrimeric G protein-linked receptors. It is likely that both Ras and Rho receive signals from the membrane receptors through different pathways and transduce signals to genes and cytoskeleton, respectively. In carcinogenesis, mutational activation of any component in the Ras signaling pathway may cause abnormal cell proliferation, whereas mutational activation of any component in the Rho signaling pathway may cause invasiveness and metastasis of carcinoma cells.

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          Author and article information

          Journal
          Int. Symp. Princess Takamatsu Cancer Res. Fund
          Princess Takamatsu symposia
          1994
          : 24
          Affiliations
          [1 ] Department of Biochemistry, Kobe University School of Medicine, Japan.
          Article
          8983086
          a91a2259-fe44-4a3a-8507-748d725f61a8
          History

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