For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
21
views
32
references
 Top references
cited by
20
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      317
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Anti-Aging and Antioxidant Potential of Paullinia cupana var. sorbilis: Findings in Caenorhabditis elegans Indicate a New Utilization for Roasted Seeds of Guarana

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background: Roasted seeds of Amazonian guarana ( Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industry for the preparation of soft drinks and as additives in energy drinks. Methods: To investigate the putative anti-aging and antioxidant activity of guarana, we used the model organism Caenorhabditis elegans. Chemical analyses were performed using high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS/MS). Results: When tested in the model system Caenorhabditis elegans, the water extract from roasted guarana seeds enhanced resistance against oxidative stress, extended lifespan and attenuated aging markers such as muscle function decline and polyQ40 aggregation. Conclusions: In the current study, we demonstrate that guarana extracts can work as a powerful antioxidant in vivo; moreover, guarana extracts exhibit anti-aging properties. Our results suggest that the biological activities of guarana go beyond the extensively reported CNS stimulation.

          Related collections

          Most cited references32

          • Record: found
          • Abstract: found
          • Article: not found

          Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans.

          Laura Herndon, Peter Schmeissner, Justyna M Dudaronek … (2002)
          The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals.
          Article 0 comments Cited 379 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Sarcopenia in the Caenorhabditis elegans pharynx correlates with muscle contraction rate over lifespan.

            Emma L. Johnston, K. Martin Chow, Catherine Wolkow … (2006)
            In muscles, sarcopenia, the loss of muscle mass, is the major cause of aging-related functional decline and frailty. Several factors are correlated with sarcopenia during aging, including contraction-related cellular injury, oxidative stress, endocrine changes and reduced regenerative potential. However the involvement of these factors has not been experimentally investigated. Here, we report that contraction-related injury may significantly promote the progression of sarcopenia in the pharynx of the nematode, Caenorhabditis elegans, a model of aging in non-regenerative tissues. Both functional and structural declines in the pharynx during aging were significantly delayed in mutants with reduced muscle contraction rates. We also examined the role of bacteria in pharynx muscle decline during aging, as previous studies reported that antimicrobial treatments could extend C. elegans lifespan. Although microbial infection may have enhanced functional decline in the pharynx during aging, it was not the sole cause of decreased pumping rates in old animals. This study identifies contraction-related injury as a factor affecting the initiation and progression of sarcopenia during aging. Further, characterization of the specific types of damage induced by muscle contraction will be helpful for understanding the underlying causes of sarcopenia.
            Article 0 comments Cited 43 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Anthocyanin-rich purple wheat prolongs the life span of Caenorhabditis elegans probably by activating the DAF-16/FOXO transcription factor.

              Wei-Wei Chen, Dolores Müller, Elke Richling … (2013)
              Colored cereals attract public attention due to their potential antioxidant properties and corresponding health benefits. Purple wheat, rich in anthocyanins, is one of the newly developed cereals on the market. Cyanidin-3-O-glucoside (42.6%) is the predominant anthocyanin in purple wheat, followed by peonidin-3-O-glucoside (39.9%) and malvidin-3-O-galactoside (17.4%). To investigate the potential antiaging and antioxidant properties of purple wheat, the nematode Caenorhabditis elegans was chosen as an experimental model organism. It was found that an anthocyanin-rich methanolic extract of purple wheat extended the mean life span of wild type worms and of mev-1(hn1) mutants, which are sensitive to oxidative stress, by 10.5 and 9.2%, respectively. Life span extension depends on the transcription factor DAF-16; no significant increase of longevity was seen in daf-16 (mgDf50) mutant worms. Translocation of DAF-16/FOXO to the nucleus implies that the transcription factor DAF-16/FOXO was activated under purple wheat treatment by inhibition of the insulin/IGF-1-like signaling pathway which includes the insulin receptor DAF-2. Moreover, purple wheat increased stress response in C. elegans as well as reduced oxidative stress. Anthocyanins of purple wheat apparently exhibit beneficial effects in C. elegans. They may exert similar properties in humans, which is an issue to be explored in future studies.
              Article 0 comments Cited 40 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                João Rocha: Role: Academic Editor
                Gerhard Litscher: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Medicines (Basel)
                Journal ID (iso-abbrev): Medicines (Basel)
                Journal ID (publisher-id): medicines
                Title: Medicines
                Publisher: MDPI
                ISSN (Electronic): 2305-6320
                Publication date (Electronic): 15 August 2017
                Publication date Collection: September 2017
                Volume: 4
                Issue: 3
                Electronic Location Identifier: 61
                Affiliations
                [1 ]Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, INF 364, D-69120 Heidelberg, Germany; hspeixoto1@ 123456gmail.com (H.P.); marianaroxocorreia@ 123456gmail.com (M.R.); wxjsz@ 123456hotmail.com (X.W.)
                [2 ]Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern, Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany; roehrig@ 123456chemie.uni-kl.de (T.R.); richling@ 123456chemie.uni-kl.de (E.R.)
                Author notes
                [* ]Correspondence: wink@ 123456uni-heidelberg.de ; Tel.: +49-6221-544880
                Author information
                https://orcid.org/0000-0001-5538-0141
                https://orcid.org/0000-0001-6063-8303
                https://orcid.org/0000-0002-7875-4510
                Article
                Publisher ID: medicines-04-00061
                DOI: 10.3390/medicines4030061
                PMC ID: 5622396
                PubMed ID: 28930275
                SO-VID: a91ea811-9cb7-4874-b766-d14aba58f62d
                Copyright © © 2017 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 30 July 2017
                Date accepted : 12 August 2017
                Categories
                Subject: Article

                Keywords: c. elegans,lifespan,oxidative stress,anti-aging,paullinia cupana,guarana
                Data availability:
                Keywords: c. elegans, lifespan, oxidative stress, anti-aging, paullinia cupana, guarana

                Comments

                Comment on this article

                scite_

                Similar content317

                See all similar

                Cited by19

                See all cited by

                Most referenced authors414

                See all reference authors