Role of Adrenal Androgens in the Development of Arteriosclerosis as Judged by Pulse Wave Velocity and Calcification of the Aorta

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Abstract

To evaluate the role of adrenal androgens in the development of arteriosclerosis, serum dehydroepiandrosterone sulfate (DHEAS), dehydroepiandrosterone (DHEA), aortic calcification and pulse wave velocity (PWV) were measured in 69 males and 119 females without overt cardiovascular disease. The steroids decreased with age in both sexes, and the reduction was significantly steeper in younger (≤40 years) than in older ( > 40 years) subjects only in females. When adjusted for age, the steroids were significantly lower in subjects with aortic calcification than in those without it, and the PWV was significantly slower in the latter. Adrenal androgens appear to retard the development and/or progression of arteriosclerosis.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1992

Publication date (Print): 1992

Publication date (Electronic): 12 November 2008

Volume: 80

Issue: 5-6

Pages: 332-338

Affiliations

^aDepartment of Geriatrics, Endocrinology and Metabolism, School of Medicine, Shinshu University, Matsumoto, Japan; ^bShinonoi General Hospital, Nagano, Japan

Article

Publisher ID: 175022 Other ID: Cardiology 1992;80:332–338

DOI: 10.1159/000175022

PubMed ID: 1451120

SO-VID: a9249421-b8ac-4c67-977e-2ba512cd8edb

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 08 April 1992

Date accepted : 18 April 1992

Page count

Pages: 7

Role of Adrenal Androgens in the Development of Arteriosclerosis as Judged by Pulse Wave Velocity and Calcification of the Aorta

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Karger: Cardiovascular System

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