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      Role of Calcium in Different Layers of Vascular Smooth Muscle in Norepinephrine Contraction

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          Abstract

          The role of calcium present in adventitial and media-intimal layers of rabbit aorta in the fast (F-) and the slow (S-) components of norepinephrine (10<sup>-5</sup>m) contraction was evaluated in this study. An increased sensitivity and decreased maximum tension to response to norepinephrine was observed in adventitia-free aorta as compared to whole aorta. Incubation in calcium-free Ringer solution with or without EDTA decreased the F-component of norepinephrine contraction of the adventitia-free aorta, whereas the F-component of the whole aorta was not affected. The S-component of both preparations was abolished in calcium-free Ringer solution. Norepinephrine increased calcium uptake into whole and adventitia-free aortic strips. An increase in calcium uptake induced by norepinephrine during the F-component of norepinephrine contraction was also observed. <sup>45</sup>Ca efflux studies revealed the presence of an exchangeable calcium fraction in the adventitial layer. These data suggest that the F-component of norepinephrine contraction is partially dependent on the extracellular calcium distributed in the adventitial layer of rabbit aorta.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1976
          1976
          18 September 2008
          : 13
          : 4
          : 193-209
          Affiliations
          Department of Pharmacology, The University of Texas Health Science Center at San Antonio, San Antonio, Tex.
          Article
          158089 Blood Vessels 1976;13:193–209
          10.1159/000158089
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
          Categories
          Research Paper

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