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      The hippo signaling pathway in development and cancer.

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      Developmental cell
      Elsevier BV

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          Abstract

          First discovered in Drosophila, the Hippo signaling pathway is a conserved regulator of organ size. Central to this pathway is a kinase cascade leading from the tumor suppressor Hippo (Mst1 and Mst2 in mammals) to the oncoprotein Yki (YAP and TAZ in mammals), a transcriptional coactivator of target genes involved in cell proliferation and survival. Here, I review recent progress in elucidating the molecular mechanism and physiological function of Hippo signaling in Drosophila and mammals. These studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.

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          Author and article information

          Journal
          Dev Cell
          Developmental cell
          Elsevier BV
          1878-1551
          1534-5807
          Oct 19 2010
          : 19
          : 4
          Affiliations
          [1 ] Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. djpan@jhmi.edu
          Article
          S1534-5807(10)00429-6 HHMIMS301276
          10.1016/j.devcel.2010.09.011
          3124840
          20951342
          a95516be-e2ef-4b49-b48a-0c85e06ac8ff
          Copyright © 2010 Elsevier Inc. All rights reserved.
          History

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