2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Pulsatile secretion of luteinizing hormone: differential suppression by ovarian steroids.

      Endocrinology
      Animals, Castration, Estradiol, pharmacology, Female, Gonadotropin-Releasing Hormone, Kinetics, Luteinizing Hormone, secretion, Pituitary Gland, drug effects, Progesterone, Sheep

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In sheep, physiological levels of estradiol and progesterone each suppress the pulses of LH characteristics of tonic LH secretion, but do so by completely different mechanisms. Estradiol treatment decreases LH pulse amplitude but not frequency and also inhibits the height of the LH peak resulting from the administration of gonadotropin-releasing hormone (GnRH). In contrast, progesterone decreases the frequency of LH pulses without reducing their amplitude or the response to exogenous GnRH. This suggests that progesterone suppresses tonic LH secretion by acting in the brain to decrease the frequency of GnRH pulses, while estradiol may suppress the response of the pituitary to GnRH and thereby decrease LH pulse amplitude.

          Related collections

          Author and article information

          Comments

          Comment on this article