6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Type 2 diabetes mellitus (T2DM) is a worldwide health problem caused by resistance to insulin action. This chronic debilitating diseaseis preceded by a stage, known as prediabetes, in which a healthy lifestyle can delay the disease. The discovery of biochemical changes in prediabetes is important to identify individuals at risk of developing T2DM and in explaining disease pathogenesis. Adiponectin is secreted by fat cells and is linked with insulin resistance. Adiponectin levels are dysregulated in prediabetic subjects. This relationship had not been tested in Jordan. We recruited 130 subjects with prediabetes and 130 control subjects. We measured serum levels of adiponectin and genotyped subjects for three single nucleotide polymorphisms (SNPs) in the ADIPOQ gene; rs266729, rs1501299 and rs2241766. In multivariate analysis, we found that serum adiponectin lowers the risk of prediabetes ( p = 0.002; odds ratio (OR), 0.764; 95% confidence interval (CI), 0.646–0.905). The rs1501299 SNP of the ADIPOQ gene was associated with prediabetes in our population ( p = 0.041). Specifically, in multivariate analysis, the GT genotype of rs1501299 increased the risk of prediabetes ( p = 0.010; OR, 2.350; 95% CI, 1.231–4.486) as well as the TT genotype ( p = 0.006; OR, 4.774; 95% CI, 1.551–14.693). Our findings indicate that serum adiponectin and SNPs in the ADIPOQ gene are associated with prediabetes in Jordan.

          Related collections

          Most cited references23

          • Record: found
          • Abstract: found
          • Article: not found

          IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040.

          To produce current estimates of the national, regional and global impact of diabetes for 2015 and 2040.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Adiponectin and protection against type 2 diabetes mellitus.

            Adiponectin is an adipocyte-derived peptide, which has anti-inflammatory and insulin-sensitising properties. We designed a nested case-control study to assess whether baseline adiponectin concentrations in plasma are independently associated with risk of type 2 diabetes. We found that adiponectin concentrations in plasma were lower among individuals who later developed type 2 diabetes than among controls (mean 5.34 microg/mL [SD 3.49] vs 6.87 microg/mL [4.58], p<0.0001). High concentrations of adiponectin were associated with a substantially reduced relative risk of type 2 diabetes after adjustment for age, sex, waist-to-hip ratio, body-mass index, smoking, exercise, alcohol consumption, education, and glycosylated haemoglobin A(1c) (odds ratio 4th vs 1st quartile 0.3 [95% CI 0.2-0.7], p=0.0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population.

              An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes. Recent genome-wide scans have mapped a diabetes susceptibility locus to chromosome 3q27, where the adiponectin gene (APM1) is located. Herein, we present evidence of an association between frequent single nucleotide polymorphisms at positions 45 and 276 in the adiponectin gene and type 2 diabetes (P = 0.003 and P = 0.002, respectively). Subjects with the G/G genotype at position 45 or the G/G genotype at position 276 had a significantly increased risk of type 2 diabetes (odds ratio 1.70 [95% CI 1.09-2.65] and 2.16 [1.22-3.95], respectively) compared with those having the T/T genotype at positions 45 and 276, respectively. In addition, the subjects with the G/G genotype at position 276 had a higher insulin resistance index than those with the T/T genotype (1.61 +/- 0.05 vs. 1.19 +/- 0.12, P = 0.001). The G allele at position 276 was linearly associated with lower plasma adiponectin levels (G/G: 10.4 +/- 0.85 microg/ml, G/T: 13.7 +/- 0.87 microg/ml, T/T: 16.6 +/- 2.24 microg/ml, P = 0.01) in subjects with higher BMIs. Based on these findings together with the observation that adiponectin improves insulin sensitivity in animal models, we conclude that the adiponectin gene may be a susceptibility gene for type 2 diabetes.
                Bookmark

                Author and article information

                Journal
                Biomolecules
                Biomolecules
                biomolecules
                Biomolecules
                MDPI
                2218-273X
                22 October 2018
                December 2018
                : 8
                : 4
                : 117
                Affiliations
                [1 ]Department of Physiology and Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; fahmughales@ 123456gmail.com (F.A.-M.); oashboul@ 123456just.edu.jo (O.A.-S.)
                [2 ]Department of Family Medicine and Public Health, School of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan; Maalqudah7@ 123456just.edu.jo (M.A.Q.); yskhader@ 123456just.edu.jo (Y.S.K.)
                [3 ]Department of Rehabilitation Sciences, School of Applied Medical Sciences, Jordan University of Science and Technology, Irbid 22110, Jordan; jarrahm@ 123456just.edu.jo
                Author notes
                [* ]Correspondence: maalfaqih@ 123456just.edu.jo ; Tel.: +962-2-720-1000
                Author information
                https://orcid.org/0000-0002-7830-6857
                Article
                biomolecules-08-00117
                10.3390/biom8040117
                6316320
                30360393
                a974cc46-36f4-44d3-ad23-cdbc3207b730
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 04 September 2018
                : 08 October 2018
                Categories
                Article

                diabetes mellitus,prediabetes,insulin resistance,adiponectin,adipoq,single nucleotide polymorphisms,rs1501299

                Comments

                Comment on this article