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      Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus.

      Nature immunology

      immunology, Adoptive Transfer, T-Lymphocyte Subsets, virology, cytology, Skin, Simplexvirus, Mice, Transgenic, Mice, Lymphocyte Activation, Immunologic Memory, Immunohistochemistry, Herpes Simplex, Ganglia, Sensory, Flow Cytometry, Chemotaxis, Leukocyte, CD8-Positive T-Lymphocytes, Animals

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          Abstract

          Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.

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          Author and article information

          Journal
          19305395
          10.1038/ni.1718

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