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      Epidemiology of gastric cancer.

      1 ,
      World journal of gastroenterology
      Baishideng Publishing Group Inc.

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          Abstract

          The incidence and mortality of gastric cancer have fallen dramatically in US and elsewhere over the past several decades. Nonetheless, gastric cancer remains a major public health issue as the fourth most common cancer and the second leading cause of cancer death worldwide. Demographic trends differ by tumor location and histology. While there has been a marked decline in distal, intestinal type gastric cancers, the incidence of proximal, diffuse type adenocarcinomas of the gastric cardia has been increasing, particularly in the Western countries. Incidence by tumor sub-site also varies widely based on geographic location, race, and socio-economic status. Distal gastric cancer predominates in developing countries, among blacks, and in lower socio-economic groups, whereas proximal tumors are more common in developed countries, among whites, and in higher socio-economic classes. Diverging trends in the incidence of gastric cancer by tumor location suggest that they may represent two diseases with different etiologies. The main risk factors for distal gastric cancer include Helicobacter pylori (H pylori) infection and dietary factors, whereas gastroesophageal reflux disease and obesity play important roles in the development of proximal stomach cancer. The purpose of this review is to examine the epidemiology and risk factors of gastric cancer, and to discuss strategies for primary prevention.

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          Author and article information

          Journal
          World J Gastroenterol
          World journal of gastroenterology
          Baishideng Publishing Group Inc.
          1007-9327
          1007-9327
          Jan 21 2006
          : 12
          : 3
          Affiliations
          [1 ] Department of Medicine and the Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, New York, NY 10032, United States.
          Article
          10.3748/wjg.v12.i3.354
          4066052
          16489633
          a9986b53-5907-45bb-a55f-e1d930d81f1e
          History

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