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      A phase II/III, multicenter, safety, efficacy, and pharmacokinetic study of dexmedetomidine in preterm and term neonates.

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          Abstract

          To investigate the safety, efficacy, and pharmacokinetic profile of dexmedetomidine in preterm and full-term neonates ≥ 28 to ≤ 44 weeks gestational age.

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          Author and article information

          Journal
          J. Pediatr.
          The Journal of pediatrics
          1097-6833
          0022-3476
          Feb 2014
          : 164
          : 2
          Affiliations
          [1 ] Department of Pediatric Critical Care Medicine, Cardiac Intensive Care Unit, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA. Electronic address: chrycx@chp.edu.
          [2 ] Department of Anesthesiology, Duke Children's Hospital, Durham, NC.
          [3 ] Department of Pediatrics, Hospital Roosevelt, Guatemala City, Guatemala.
          [4 ] Neonatology, Greenville Hospital System, Greenville, SC.
          [5 ] Department of Pediatrics, West Virginia University Hospitals and Clinics, Ruby Memorial Hospital, Morgantown, WV.
          [6 ] Global Clinical R & D and Medical Affairs, Hospira Inc, Lake Forest, IL.
          [7 ] Department of Anesthesiology, Loyola University Medical Center, Maywood, IL.
          Article
          S0022-3476(13)01230-4
          10.1016/j.jpeds.2013.10.002
          24238862
          a9a1f04b-8a36-4233-b637-109e6c74da61
          Copyright © 2014 The Authors. Published by Mosby, Inc. All rights reserved.
          History

          AE,AUC,Adverse event,Area under the concentration curve,BP,Blood pressure,CL(W),HR,Half-life,Heart rate,LD,Loading dose,MD,Maintenance dose,N-PASS,Neonatal Pain, Agitation, Sedation Scale,PK,Pharmacokinetic,Plasma clearance,t(1/2)

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